TAILIEUCHUNG - Báo cáo khoa học: Combining theoretical analysis and experimental data generation reveals IRF9 as a crucial factor for accelerating interferon a-induced early antiviral signalling

Type I interferons (IFN) are important components of the innate antiviral response. A key signalling pathway activated by IFNais the Janus kinase⁄ signal transducer and activator of transcription (JAK⁄STAT) pathway. Major components of the pathway have been identified. However, critical kinetic properties that facilitate accelerated initiation of intracellular antiviral signalling and thereby promote virus elimination remain to be determined. | Combining theoretical analysis and experimental data generation reveals IRF9 as a crucial factor for accelerating interferon a-induced early antiviral signalling Tim Maiwald1 z Annette Schneider2 z Hauke Busch3 Sven Sahle1 Norbert Gretz4 Thomas S. Weiss5 Ursula Kummer1 and Ursula Klingmuller2 1 Heidelberg University Department Modeling of BiologicalProcesses BIOQUANT Institute of Zoology Germany 2 German Cancer Research Center Division Systems Biology of SignalTransduction BIOQUANT DKFZ-ZMBH Alliance Heidelberg Germany 3 Freiburg Institute for Advanced Studies FRIAS AlbertstraBe 19 and Center for Biosystems Analysis ZBSA University of Freiburg Germany 4 Heidelberg University MedicalFaculty Mannheim Germany 5 University MedicalCenter Regensburg Center for Liver CellResearch Germany Keywords antiviral signalling interferon a IRF9 kinetic model signal transduction Correspondence U. Klingmuller Division Systems Biology of Signal Transduction German Cancer Research Center Im Neuenheimer Feld 280 Heidelberg 69120 Germany Fax 49 6221 42 4488 Tel 49 6221 42 4481 E-mail Database The mathematicalmodeldescribed here has been submitted to the Online Cellular Systems Modelling Databaseand can be accessed at http database maiwald free of charge These authors contributed equally to this work Type I interferons IFN are important components of the innate antiviral response. A key signalling pathway activated by IFNa is the Janus kinase signal transducer and activator of transcription JAK STAT pathway. Major components of the pathway have been identified. However critical kinetic properties that facilitate accelerated initiation of intracellular antiviral signalling and thereby promote virus elimination remain to be determined. By combining mathematical modelling with experimental analysis we show that control of dynamic behaviour is not distributed among several pathway components but can be primarily attributed to interferon

• Báo cáo khoa học
• Scientific reports
• scientific research
• biochemistry
• Crystal structure
• medical analysis
• biochemical studies
• collection of scientific reports
• industry reports philosophy of history reports
• reports in literature
• a scientific b shirt
• presentation of scientific reports
• reports on literature
• philosophy statement
• documents
• studies English language and English language communication and English language commercial
• progress reports at scientific collections
• agronomic reports
• reports in physics
• biology reports
• thematic biological
• induced geometry
• mathematical topics
• quantum mechanics
• physics
• reporting mathematics
• physics reports
• livestock reports
• physical reports
• research physicist
• specializing in physics
• mathematical statements
• mathematical equations
• English pronunciation
• presentation report
• agricultural reports
• technical crops
• bio technology
• English reports
• presentation reports
• mathematical knowledge
• reports of mathematics
• represented
• Wilf on packing distinct
• Tur´n density
• mathematical works
• patterns in a permutation
• statements and documents scientific reports
• reports agronomy
• biotechnology
• plants Vietnam
• specialized biological
• microbiological methods
• presenting the report
• anti bacterial properties of shrimp
• energy exchange
• engineering chicken
• Path counting
• random matrix theory
• Even circuits
• prescribed clockwise parity
• Correspondence between
• algorithmic characterizations
• Finding Induced Acyclic
• Random Digraphs
• Nonexistence results
• Hadamard like matrices
• Voltage Graphs
• Group Presentations
• Cages mathematical knowledge
• Dominance Order
• Graphical Partitions
• On the functions
• values in [α(G
• Box With Translates
• Two Given Rectangular Brick
• On the q analogue
• the sum of cubes