TAILIEUCHUNG - Báo cáo khoa học: Cell death-inducing DFF45-like effector, a lipid droplet-associated protein, might be involved in the differentiation of human adipocytes

Cell death-inducing DFF45-like effector (CIDE) family proteins, including cell death-inducing DFF45-like effector A (CIDEA), cell death-inducing DFF45-like effector B (CIDEB) and cell death-inducing DFF45-like effec-tor C (CIDEC) [fat-specific protein of 27 kDa in rodent (FSP27) in rodents], were originally identified by their sequence homology to the N-terminal region of DNA fragmentation factor DFF40⁄45. | ỊFEBS Journal Cell death-inducing DFF45-like effector a lipid droplet-associated protein might be involved in the differentiation of human adipocytes Fanfan Li1 Yu Gu1 Wenpeng Dong2 Hang Li1 Liying Zhang1 Nanlin Li3 Wangzhou Li4 Lijun Zhang1 Yue Song1 Lina Jiang1 Jing Ye1 and Qing Li1 1 State Key Laboratory of Cancer Biology Department of Pathology Xijing Hospital Fourth Military MedicalUniversity Xi an China 2 State Key Laboratory of Cancer Biology Xijing Hospitalof Digestive Diseases Fourth Military MedicalUniversity Xi an China 3 Department of Vascular and Endocrine Surgery Xijing Hospital Fourth Military MedicalUniversity Xi an China 4 Department of Plastic and Burns Tangdu Hospital Fourth Military MedicalUniversity Xi an China Keywords adipocyte differentiation cell death-inducing DFF45-like effector C CIDEC obesity peroxisome proliferator-activated receptor-c PPARc RNAi Correspondence Qing Li and Jing Ye State Key Laboratory of Cancer Biology Department of Pathology Xijing Hospital Fourth Military MedicalUniversity 15 Changle West Road Xi an 710032 China Fax 86 29 84776793 Tel 86 29 84774541 E-mail liqing@ yejing@ Received 12 March 2010 revised 29 July 2010 accepted 3 August 2010 doi Cell death-inducing DFF45-like effector CIDE family proteins including cell death-inducing DFF45-like effector A CIDEA cell death-inducing DFF45-like effector B CIDEB and cell death-inducing DFF45-like effector C CIDEC fat-specific protein of 27 kDa in rodent FSP27 in rodents were originally identified by their sequence homology to the N-terminal region of DNA fragmentation factor DFF40 45. Recent reports have revealed that CIDE family proteins play important roles in lipid metabolism. Several studies involving knockdown mice revealed that FSP27 is a lipid droplet-targeting protein that can promote the formation of lipid droplets. However the detailed roles of human CIDEC in the differentiation of human adipocytes remain .

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