TAILIEUCHUNG - Báo cáo khoa học: A structural overview of the PDI family of proteins

Protein disulfide isomerases (PDIs) are enzymes that mediate oxidative pro-tein folding in the endoplasmic reticulum. Understanding of PDIs has historically been hampered by lack of structural information. Over the last several years, partial and full-length PDI structures have been solved at an increasing rate. | REVIEW ARTICLE A structural overview of the PDI family of proteins Guennadi Kozlov Pekka Maattanen David Y. Thomas and Kalle Gehring Department of Biochemistry Groupe de Recherche Axe sur la Structure des Proteines McGillUniversity Montreal Quebec Canada Keywords disulfide endoplasmic reticulum ERp44 ERp57 ERp72 PDI protein folding protein structure thioredoxin-like X-ray crystallography Correspondence K. Gehring Department of Biochemistry McGillUniversity 3649 Promenade Sir William Osler Montreal Quebec H3G 0B1 Canada Fax 1 514 398 2983 Tel 1 514 398 7287 E-mail Received 8 April2010 revised 11 July 2010 accepted 27 July 2010 doi Protein disulfide isomerases PDIs are enzymes that mediate oxidative protein folding in the endoplasmic reticulum. Understanding of PDIs has historically been hampered by lack of structural information. Over the last several years partial and full-length PDI structures have been solved at an increasing rate. Analysis of the structures reveals common features shared by several of the best known PDI family members and also unique features related to substrate and partner binding sites. These exciting breakthroughs provide a deeper understanding of the mechanisms of oxidative protein folding in cells. Introduction Protein disulfide isomerase PDI was the first protein folding catalyst discovered 1 . Since its discovery more than 40 years ago studies of this remarkable enzyme have shown that PDI acts as a dithiol-disulfide oxido-reductase that is capable of reducing oxidizing and isomerizing disulfide bonds. Independently of its redox activity PDI can also act as a chaperone both in vitro 2 and in vivo 3 . PDI is the founding member of a family of 20 related mammalian proteins that are chiefly located and function in the endoplasmic reticulum ER Fig. 1 . PDI family members are abundant and play a significant role in protein folding and quality control in the calcium-rich oxidative .

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