TAILIEUCHUNG - Biomedical imaging in experimenal neuoscience

The goals of experimental neuroscience research are fundamentally to gain mechanistic understanding of the pathology of disease in order to identify appropriate targets for potential pharmacological intervention and evaluation of putative therapies. With the advances in gene manipulation and transgene technologies, we have unprecedented ability to generate animal models of disease that more closely mimic the clinical conditions. Noninvasive techniques capable of investigating altered pathophysiologies are now of paramount importance. Conventional methods that rely on histological and/or immunohistochemical staining demand the selective sacrifices of large cohorts of animals and include inherent assumptions of population homogeneity. Noninvasive imaging offers the obvious attractions of reducing sample sizes, use of individual data for internal. | BIOMEDJCflllMflGING ỊNEXPẼRIMẼKỊÌỈL NEUROSCIENCE Edited by Nick van Bruggen Timothy Roberts CRC PRESS Boca Raton London New York Washington . 2003 CRC Press LLC Library of Congress Cataloging-in-Publication Data Biomedical imaging in experimenal neuoscience edited by Nick van Bruggen and Timothy Roberts. p. cm. Methods new frontiers in neuroscience Includes bibliographical references and index. ISBN 0-8493-0122-X alk. paper 1. Brain Imaging. 2. Brain Magnetic resonance imaging. I. van Bruggen Nick. II. Roberts Timothy Timothy P. L. III. Methods new frontiers in neuroscience series .B55 2002 dc21 2002031093 This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted with permission and sources are indicated. A wide variety of references are listed. Reasonable efforts have been made to publish reliable data and information but the authors and the publisher cannot assume responsibility for the validity of all materials or for the consequences of their use. Neither this book nor any part may be reproduced or transmitted in any form or by any means electronic or mechanical including photocopying microfilming and recording or by any information storage or retrieval system without prior permission in writing from the publisher. All rights reserved. Authorization to photocopy items for internal or personal use or the personal or internal use of specific clients may be granted by CRC Press LLC provided that per page photocopied is paid directly to Copyright Clearance Center 222 Rosewood Drive Danvers MA 01923 USA. The fee code for users of the Transactional Reporting Service is ISBN 0-8493-0122-X 03 . The fee is subject to change without notice. For organizations that have been granted a photocopy license by the CCC a separate system of payment has been arranged. The consent of CRC Press LLC does not extend to copying for general distribution for promotion for creating new works or for .

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