TAILIEUCHUNG - Báo cáo y học: " Hepatitis B virus genotypes and precore and core mutants in UAE patients"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Hepatitis B virus genotypes and precore and core mutants in UAE patients | Alfaresi et al. Virology Journal 2010 7 160 http content 7 1 160 VIROLOGY JOURNAL RESEARCH Open Access Hepatitis B virus genotypes and precore and core mutants in UAE patients Mubarak Alfaresi Abida Elkoush Hajer Alshehhi Azza Alzaabi and Adeel Islam Abstract Background Knowledge of the HBV genotype with which a patient is infected is crucial information for a physician to have when planning clinical treatment for that patient. Previous studies have suggested that there are possible differences in the pathogenicity and therapeutic response of different HBV genotypes. However the prevalence of the various HBV genotypes and Precore and Core mutations is unknown in the UAE. Therefore we sought to determine the prevalence of the different HBV genotypes in the UAE population. Methodology Principal Findings A total of 88 HBsAg-positive patients were included in the study. A method for genotyping and subtyping HBV by partial HBsAg gene sequencing using primers that are complementary to all known genotypes was used. Precore and core region of these viruses were also sequenced in 88 patients. HBV genotype D was the most prevalent genotype identified in our study population followed by genotypes A and C . The following subtypes were isolated ayw2 adw2 and adw . The HBV-DNA viral load was higher in HBeAg-positive patients than it was in patients who were HBeAg-negative. Precore mutants were found in 51 of 88 patients. Mutations in the basal core promotor were found in 22 of 88 patients. Conclusion Significance HBV infection is a major health problem in the UAE and while genotypes B and C are the most prevalent HBV genotypes in the Asian population our study reveals that genotype D is the predominant genotype that is present in the UAE. More patients were HBeAg-negative than were HBeAg-positive in our study sample which could be due to the duration of infection of the included patients. Additionally the viral loads of the

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