TAILIEUCHUNG - Báo cáo khoa học: Spatio-temporal distribution of fatty acid-binding protein 6 (fabp6) gene transcripts in the developing and adult zebrafish (Danio rerio)

We have determined the structure of the fatty acid-binding protein 6 (fabp6) gene and the tissue-specific distribution of its transcripts in embryos, larvae and adult zebrafish (Danio rerio). Like most members of the vertebrate FABPmultigene family, the zebrafishfabp6 gene contains four exons separated by three introns. | ỊFEBS Journal Spatio-temporal distribution of fatty acid-binding protein 6 fabp6 gene transcripts in the developing and adult zebrafish Danio rerio Fernanda A. Alves-Costa1 Eileen M. Denovan-Wright2 Christine Thisse3 Bernard Thisse3 and Jonathan M. Wright1 1 Department of Biology Dalhousie University Halifax Canada 2 Department of Pharmacology Halifax Canada 3 Department of Cell Biology University of Virginia Health Sciences Center Charlottesville VA USA Keywords adrenal gland conserved gene synteny ileum in situ hybridization linkage group assignment Correspondence J. M. Wright Department of Biology Dalhousie University Halifax NS Canada B3H 4J1 Fax 1 902 494 3736 Tel 1 902 494 6468 E-mail jmwright@ Website http biology ca Present address Departamento de Genetica Instituto de Bio-ciencias UNESP - Universidade Estadual Paulista CEP 18618 Botucatu Sao Paulo Brazil Database Sequences for the six fabp6 clones have been submitted to the DDBJ EMBL GenBank databases under the accession numbers EU665309 EU665310 EU665311 EU665312 EU665313 and EU665314 Received 20 February 2008 revised 21 March 2008 accepted 24 April 2008 doi We have determined the structure of the fatty acid-binding protein 6 fabp6 gene and the tissue-specific distribution of its transcripts in embryos larvae and adult zebrafish Danio rerio . Like most members of the vertebrate FABP multigene family the zebrafish fabp6 gene contains four exons separated by three introns. The coding region of the gene and expressed sequence tags code for a polypeptide of 131 amino acids 14 kDa pI . The putative zebrafish Fabp6 protein shared greatest sequence identity with human FABP6 compared to other orthol-ogous mammalian FABPs and paralogous zebrafish Fabps. Phylogenetic analysis showed that the zebrafish Fabp6 formed a distinct clade with the mammalian FABP6s. The zebrafish fabp6 gene was assigned to linkage group chromosome 21 by radiation hybrid mapping. .

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