TAILIEUCHUNG - Báo cáo khoa học: The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 (TTF-1) and GATA-6 transcription factors

MUC5Bis one of the major mucin genes expressed in the respiratory tract. Previous studies in our laboratory have demonstrated that MUC5B is expressed in human lung adenocarcinomas and during lung morphogenesis. Moreover, in human lung adenocarcinoma tissues, a converse correlation between MUC5B and thyroid transcription factor-1 (TTF-1) expression | BFEBS Journal The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 TTF-1 and GATA-6 transcription factors Nicolas Jonckheere1 2 Amelie Velghe1 Marie-Paule Ducourouble1 2 Marie-Christine Copin1 2 3 Ingrid B. Renes4 and Isabelle Van Seuningen1 2 1 Inserm U837 Jean Pierre Aubert Research Center Team 5 Mucins epithelialdifferentiation and carcinogenesis Lille Cedex France 2 Universite Lille Nord de France Lille Cedex France 3 Centre de Biologie-Pathologie Centre Hospitalier Regionalet Universitaire de Lille Lille France 4 Laboratory of Pediatrics Division of Neonatology Erasmus MC-Sophia Hospital Rotterdam the Netherlands Keywords differentiation GATA Muc5b mucin TTF-1 Correspondence N. Jonckheere Inserm U837 Team 5 Mucins epithelialdifferentiation and carcinogenesis Rue Polonovski 59045 Lille Cedex France Fax 33 320 53 85 62 Tel 33 320 29 88 50 E-mail Received 11 August 2010 revised 20 October 2010 accepted 3 November 2010 doi MUC5B is one of the major mucin genes expressed in the respiratory tract. Previous studies in our laboratory have demonstrated that MUC5B is expressed in human lung adenocarcinomas and during lung morphogenesis. Moreover in human lung adenocarcinoma tissues a converse correlation between MUC5B and thyroid transcription factor-1 TTF-1 expression a lung-specific transcription factor has been established. However the molecular mechanisms that govern the regulation of MUC5B expression in the lung are largely unknown. In order to better understand the biological role of MUC5B in lung pathophysiology we report the characterization of the promoter region of the mouse Muc5b mucin gene. The promoter is flanked by a TATA box TACATAA identical to that in the human gene. Human and murine promoters share similarity over the first 170 nucleotides. By RT-PCR co-transfection studies and gel-shift assays we show that Muc5b promoter activity is completely .

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