TAILIEUCHUNG - Chapter 084. Head and Neck Cancer (Part 6)

Chemoprevention β-Carotene and cis-retinoic acid can lead to the regression of leukoplakia. However, cis-retinoic acid does not reduce the incidence of second primaries Treatment Complications Complications from treatment of head and neck cancer are usually correlated to the extent of surgery and exposure of normal tissue structures to radiation. Currently, the extent of surgery has been limited or completely replaced by chemotherapy and radiation therapy as the primary approach. Acute complications of radiation include mucositis and dysphagia. Long-term complications include xerostomia, loss of taste, decreased tongue mobility, second malignancies, dysphagia, and neck fibrosis. The complications of chemotherapy vary with the regimen. | Chapter 084. Head and Neck Cancer Part 6 Chemoprevention 0-Carotene and m-retinoic acid can lead to the regression of leukoplakia. However m-retinoic acid does not reduce the incidence of second primaries Treatment Complications Complications from treatment of head and neck cancer are usually correlated to the extent of surgery and exposure of normal tissue structures to radiation. Currently the extent of surgery has been limited or completely replaced by chemotherapy and radiation therapy as the primary approach. Acute complications of radiation include mucositis and dysphagia. Long-term complications include xerostomia loss of taste decreased tongue mobility second malignancies dysphagia and neck fibrosis. The complications of chemotherapy vary with the regimen used but usually include myelosuppression mucositis nausea and vomiting and nephrotoxicity with cisplatin . The mucosal side effects of therapy can lead to malnutrition and dehydration. Many centers address issues of dentition before starting treatment and some place feeding tubes to assure control of hydration and nutrition intake. About 50 of patients develop hypothyroidism from the treatment thus thyroid function should be monitored. Salivary Gland Tumors Most benign salivary gland tumors are treated with surgical excision and patients with invasive salivary gland tumors are treated with surgery and radiation therapy. Neutron radiation may be particularly effective. These tumors may recur regionally adenoidcystic carcinoma has a tendency to recur along the nerve tracks. Distant metastases may occur as late as 10a 20 years after the initial diagnosis. For metastatic disease therapy is given with palliative intent usually chemotherapy with doxorubicin and or cisplatin. Further Readings Adelstein DJ et al An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer. J Clin Oncol 21 92 2003

• Y học thường thức
• Head and Neck Cancer
• bệnh học và điều trị
• bài giảng bệnh học
• tài liệu y khoa
• Harrisons Internal Medicine
• BMC Cancer
• Head and neck squamous cell carcinoma
• Immune checkpoint inhibitors
• Survival in head and neck cancer
• Alcohol consumption
• Cigarette smoking
• Cohort studies
• Head neck cancer
• Head neck cancer subtypes
• Progressive resistance training
• Physical activity
• Body composition
• Clinical cohort
• Prognosis research
• Patient reported outcomes
• Sexual history
• Quality of life
• Biological samples
• Cell Line Microarray
• Potential immunohistochemical biomarkers
• Triple treatment combination
• Immunotherapy targeting
• Metastatic head
• Neck squamous cell carcinoma
• Cancer stem cells
• Side population
• Delayed neck metastasis
• Inflammatory marker
• Systemic inflammation
• Nonstandard treatment
• Patient compliance
• Cumulative incidence
• Esophageal cancer
• Metachronous cancer
• Young onset
• Head and neck
• Phase III
• Squamous cell carcinoma
• Overall survival
• Platinum therapy
• Narrow band imaging
• Second primary cancer
• Radiation dermatitis
• Topical steroid
• Neck cancer
• Patient derived xenograft
• Squamous cell cancer
• Anti cancer therapeutics
• Warburg effect
• Alternative splicing
• Pyruvate Kinase muscle isoenzyme
• Cancer cells
• Single nucleotide polymorphism
• Personalized medicine
• 5 lipoxygenase
• Representative endocannabinoids
• Effectively inhibited
• Treatment outcome
• Induction chemotherapy
• Neck squamous cells carcinomas
• Metabolic statuses
• CUP syndrome
• Delayed adjuvant therapy
• Advanced head and neck cancer
• Neck dissection
• Human papillomavirus
• Oropharyngeal cancer
• Laryngeal cancer
• Oral cancer
• Chemo radiotherapy exhibiting weak
• Locoregional cancer
• Aspiration pneumonia
• Risk factors
• Cancer related mortality
• Tumor growth
• Meta analysis
• Cancer worldwide
• Anti CD44 v6 antibody
• Antineoplastic treatment
• Indicating greater difficulties
• Circulating tumor cell
• Circulating tumor DNA
• Oral cavity cancer preclinical model