TAILIEUCHUNG - Neurodegenerative Biomarkers in Healthy Elderly

It can happen in an instant: reaching on a wobbly stool for something located on a high shelf, tripping over uneven pavement, slipping on a rug or a patch of ice, or getting up from a bed, a bath, a toilet or a chair. It can happen in a person’s home, in the community, while a patient is in an acute care hospital, or as a resident in a long-term care home. There are numerous ways a person can suddenly trip or lose his or her balance, and the result is often an injury, hospitalization – or even death. It is. | Neurodegenerative Biomarkers in Healthy Elderly - with special reference to the preclinical pattern of biological and cognitive markers for Alzheimer s disease Erik Stomrud MD Clinical Memory Research Unit Department of Clinical Sciences Malmo Faculty of Medicine Lund University Doctoral Thesis With due permission of the Faculty of Medicine at Lund University to be publicly defended on December 12 2009 at am in the Main Lecture Hall at the Clinical Research Centre CRC Malmo University Hospital Entrance 72 Malmo Sweden Supervisors Elisabet Londos Associate professor Lennart Minthon Associate professor Oskar Hansson Associate professor Lund University Chair at Thesis Defence Bengt Jeppsson Professor Lund University External Faculty Examiner Maria Eriksdotter-Jonhagen Associate professor Karolinska Institutet Stockholm Sweden Examination Board Henrik Anckarsater Professor Gõteborg University Martin Ingelsson Associate professor Uppsala University Ằsa Westrin Associate professor Lund University Malmo 2009 Organization LUND UNIVERSITY Faculty of Medicine Department of Clinical Sciences Malmõ Clinical Memory Research Unit Document name DOCTORAL DISSERTATION Date of issue December 12th 2009 Sponsoring organization Author s Erik stomrud Title and subtitle Neurodegenerative biomarkers in healthy elderly - with special reference to the preclinical pattern of biological and cognitive markers for Alzheimer s disease Abstract Background Alzheimer s disease AD is a neurodegenerative disorder characterized by tau and amyloid brain pathology. With the gradual degeneration of neurons cognitive symptoms will arise and the affected individual will eventually develop AD dementia. The neuropathologic hallmarks of AD have been observed also in cognitively healthy individuals which has led to the assumption that the disorder has a long preclinical phase. Several biological markers for detecting and predicting AD have been validated over the years where CSF biomarkers are one of the

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