TAILIEUCHUNG - Báo cáo khoa học: P01 – Genomes: structure, information and epigenetic control

ADAMTS (A Disintegrin and Metalloproteinase with Thrombo-spondin Motifs) are zinc dependent proteases have a part in impor-tant physiologic processes such as development, homeostasis and fertility. To date, 19 different ADAMTS proteases have been iden-tified. ADAMTS-2 is a member of ADAMTS family. Together with ADAMTS-3 and ADAMTS-14, ADAMTS-2 has procollagen N-proteinase activity. | P01 - Genomes structure information and epigenetic control IFEBS Journal Abstracts POSTER PRESENTATIONS P01 - Genomes structure information and epigenetic control Cloning of human ADAMTS-2 Promoter Strategies for cloning extremely GC rich promoters M. Alper and F. Kockar Faculty of Science and Literature Department of Biology Balikesir University Balikesir Turkey ADAMTS A Disintegrin and Metalloproteinase with Thrombospondin Motifs are zinc dependent proteases have a part in important physiologic processes such as development homeostasis and fertility. To date 19 different ADAMTS proteases have been identified. ADAMTS-2 is a member of ADAMTS family. Together with ADAMTS-3 and ADAMTS-14 ADAMTS-2 has procollagen N-proteinase activity. It mainly processes type I II III and V collagen precursors that have a key role for all humans. This process is important for the correct fibril and fiber conformation of connective tissue. Therefore ADAMTS-2 has been implicated in some human diseases like Ehler-Danlos syndrome type VIIC and dermatosparaxis. Recently It also has been postulated it s anti-angiogenic and anti-tumoral functions. ADAMTS-2 gene expression was determined in some tissues like aorta bone skin tendon bladder retina lung kidney liver and skeletal isn t any study about transcriptional regulation of this gene. Therefore this study is focused on transcriptional regulation of ADAMTS-2 gene. Different strategies for the amplication of ADAMTS-2 promotor that has extremely secondary structures and 80 GC rich sequences have been used without any success. These strategies are the use of different thermostable enzymes some additives and enhancers different primers PCR techniques such as touch-down PCR and genome walker strategies. Putative 760bp of ADAMTS-2 promoter region was able to amplify from human genomic DNA using some additives and cloned in pGEM-T-Easy. These GC-rich amplications strategies will be discussed in detail. Keywords ADAMTS-2 .

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