TAILIEUCHUNG - Báo cáo khoa học: 2-Amino-nonyl-6-methoxyl-tetralin muriate activity against Candida albicans augments endogenous reactive oxygen species production – a microarray analysis study

Candidainfections have become an increasingly significant problem, mainly because of the widespread nature ofCandidaand drug resistance. There is an urgent need to develop new classes of drugs for the treatment of oppor-tunistic Candidainfections, especially in medically complex patients. | IFEBS Journal 2-Amino-nonyl-6-methoxyl-tetralin muriate activity against Candida albicans augments endogenous reactive oxygen species production - a microarray analysis study 1 _2 2 2 3 1 Rong Mei Liang Xiao Lan Yong Yun Ping Jiang Yong Hong Tan Bao Di Dai Shi Hua Wang3 Ting Ting Hu2 Xi Chen2 Nan Li2 Zhao Hui Dong2 Xiao Chun Huang2 Jun Chen2 Yong Bing Cao1 and Yuan Ying Jiang1 1 Drug Development Center Schoolof Pharmacy Second Military MedicalUniversity Shanghai China 2 Department of ClinicalPharmacy GeneralHospitalof Chengdu Military Command Region Chengdu China 3 Department of Pharmacy GeneralHospitalof Chengdu Military Command Region Chengdu China Keywords 10b action mechanism Candida albicans microarray analysis ROS Correspondence Y. B. Cao and Y. Y. Jiang Drug Development Center Schoolof Pharmacy Second Military MedicalUniversity 325 Guohe Road Shanghai 200433 China Fax 86 021 6549 0641 Tel 86 021 8187 1357 86 021 8187 1275 E-mail jiangyysmmu@ ybcao@ Received 21 October 2010 revised 14 December 2010 accepted 18 January 2011 doi Candida infections have become an increasingly significant problem mainly because of the widespread nature of Candida and drug resistance. There is an urgent need to develop new classes of drugs for the treatment of opportunistic Candida infections especially in medically complex patients. Previous studies have confirmed that 2-amino-nonyl-6-methoxyl-tetralin muriate 10b possesses powerful antifungal activity in vitro against Candia albicans. To clarify the underlying action mechanism an oligonucleotide microarray study was performed in C. albicans SC5314 without and with 10b treatment. The analytical results showed that energy metabolism-related genes including glycolysis-related genes PFK1 CDC19 and HXK2 fermentation-related genes PDC11 ALD5 and ADH1 and respiratory electron transport chain-related genes CBP3 COR1 and QCR8 were downregu-lated significantly. Functional analysis .

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