TAILIEUCHUNG - Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain

The kinase noncatalytic C-lobe domain (KIND) is a putative protein–protein interaction module. Four KIND-containing proteins, Spir-2 (actin-nuclear factor), PTPN13 (protein tyrosine phosphatase), FRMPD2 (scaffold protein) and very-KIND (v-KIND) (brain-specific Ras guanine nucleotide exchange factor), have been identified to date. | IFEBS Journal Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2 and its role in dendrite growth - structure and function of the second kinase noncatalytic C-lobe domain Jinhong Huang1 Asako Furuya1 Kanehiro Hayashi1-3 and Teiichi Furuichi1 2 4 1 Laboratory for Molecular Neurogenesis RIKEN Brain Science Institute Saitama Japan 2 JST CREST Kawaguchi Saitama Japan 3 Research Institute of PharmaceuticalSciences Musashino University Tokyo Japan 4 Faculty of Science and Technology Tokyo University of Science Chiba Japan Keywords dendrite growth KIND domain MAP2 protein-protein interaction RasGEF Correspondence T. Furuichi Laboratory for Molecular Neurogenesis RIKEN Brain Science Institute 2-1 Hirosawa Wako 351-0198 Japan Fax 81 48 467 6079 Tel 81 48 467 5906 E-mail tfuruichi@ Present address Discovery Development Laboratory I Hanno Research Center Taiho Pharmaceutical Co. Ltd Saitama Japan Received 5 January 2011 revised 19 February 2011 accepted 28 February 2011 doi The kinase noncatalytic C-lobe domain KIND is a putative protein-protein interaction module. Four KIND-containing proteins Spir-2 actin-nuclear factor PTPN13 protein tyrosine phosphatase FRMPD2 scaffold protein and very-KIND v-KIND brain-specific Ras guanine nucleotide exchange factor have been identified to date. Uniquely v-KIND has two KINDs . KIND1 and KIND2 whereas the other three proteins have only one. The functional role of KIND however remains unclear. We previously demonstrated that v-KIND interacts with the high-molecular weight microtubule-associated protein 2 MAP2 a dendritic microtubule-associated protein leading to negative regulation of neuronal dendrite growth. In the present study we analyzed the structure-function relationships of the v-KIND-MAP2 interaction by generating a series of mutant constructs. The interaction with endogenous MAP2 in mouse cerebellar granule cells was specific to v-KIND .

• Báo cáo khoa học
• Scientific reports
• scientific research
• Structural biochemistry
• noncatalytic
• microtubule
• medical knowledge
• collection of scientific reports
• industry reports philosophy of history reports
• reports in literature
• a scientific b shirt
• presentation of scientific reports
• reports on literature
• philosophy statement
• documents
• studies English language and English language communication and English language commercial
• progress reports at scientific collections
• agronomic reports
• reports in physics
• biology reports
• thematic biological
• induced geometry
• mathematical topics
• quantum mechanics
• physics
• reporting mathematics
• physics reports
• livestock reports
• physical reports
• research physicist
• specializing in physics
• mathematical statements
• mathematical equations
• English pronunciation
• presentation report
• agricultural reports
• technical crops
• bio technology
• English reports
• presentation reports
• mathematical knowledge
• reports of mathematics
• represented
• Wilf on packing distinct
• Tur´n density
• mathematical works
• patterns in a permutation
• statements and documents scientific reports
• reports agronomy
• biotechnology
• plants Vietnam
• specialized biological
• microbiological methods
• presenting the report
• anti bacterial properties of shrimp
• energy exchange
• engineering chicken
• Path counting
• random matrix theory
• Even circuits
• prescribed clockwise parity
• Correspondence between
• algorithmic characterizations
• Finding Induced Acyclic
• Random Digraphs
• Nonexistence results
• Hadamard like matrices
• Voltage Graphs
• Group Presentations
• Cages mathematical knowledge
• Dominance Order
• Graphical Partitions
• On the functions
• values in [α(G
• Box With Translates
• Two Given Rectangular Brick
• On the q analogue
• the sum of cubes