TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 112

Pharmaceutical Substances Syntheses, Patents, Applications - Part 112. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Isoxicam I 1111 CH3 Z - -formyl-crotonic acid cf. retina synthesis COOH Reference s Garbers . et al. J. Chem. Soc. C JSOOAX 1968 1982. Z -ß-formylcrotonic acid Conradie . et al. J. Chem. Soc. C JSOOAX 1964 594. combination with taurine US 4 545 977 Searle appl. . medical use DE2061 507 Hoffmann-La Roche appl. prior. . US 3 746 730 Hoffmann-La Roche appl. GB-prior. . Formulation s cps. mg 5 mg 10 mg 20 mg gel Trade Namefs D ISOTREX Stiefel Roaccutane Roche 1986 Roaccutane Roche Roaccutan Roche 1985 GB Isotrex Stiefel I Roaccutane Roche F Isotrex Stiefel Isotrexin Stiefel USA Accutane Roche 1982 Isoxicam M Use anti-inflammatory RN 34552-84-6 MF C14H lN O5S MW EINECS 252-084-5 LD5 5 g kg R . CN 4-hydroxy-2-methyl-7V- 5-methyl-3-isoxazolyl -2H-1 2-benzothiazine-3-carboxamide 1 1 -dioxide OH 0 3- ethoxycarbonyl- 4- hydroxy-2-methyl-2H-1 2-benzothiazine 1 1 -dioxide cf. piroxicam synthesis ch3 3-amino-5-methyl-isoxozole Reference s DOS 2 208 351 Warner-Lambert appl. USA-prior. . Lombardino . Wiseman . J. Med. Chem. JMCMAR 14 973 1971 . Zinnes H. et al. J. Med. Chem. JMCMAR 25 12 1982 . Formulation s cps. 100 mg 1112 I Isoxsuprine Trade Name s D Pacyl Adenylchemie wfm F Vectren Substantia wfm J Floxicam Menarini wfm Maxicam Parke Davis wfm Isoxsuprine ATC C04AA01 Use vasodilator RN 395-28-8 MF ClfiH23NO3 MW EINECS 206-898-2 LD50 48 mg kg M . 200 mg kg M . CN 4-hydroxy-a- 1 - 1 -methyl-2-phenoxyethyl amino ethyl benzenemethanol hydrochloride RN 579-56-6 MF C aH23NO3 HC1 MW EINECS 209-443-6 LD50 61 mg kg M . g kg M . g kg R . 57 mg kg dog . g kg dog . 4-hydroxy-norephedrine ch3 1-phenoxy-2-bromopropane 4 -benzyloxypropiophenone CHj phencxypropane 1 Isoxsuprine Reference s US 3 056 836 Philips NL-prior. . GB 832 286 Philips appl. NL-prior. . GB 832 287 Philips

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