TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 103

Pharmaceutical Substances Syntheses, Patents, Applications - Part 103. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Hydrocortisone H 1021 Trade Name s D Dicodid Knoll 1 Dicodid Knoll wfm USA Hycotuss Endo -comb. Tussend Monarch -comb. numerous combination preparations Hydrocortisone ATC A01AC03 A07EA02 D07AA02 C05AA01 D07XA01 H02AB09 S01BA02 S01CB03 S02BA01 Use glucocorticoid anti-inflammatory RN 50-23-7 MF C21H30O5 MW EINECS 200-020-1 LD50 500 mg kg M . 150 mg kg R . 449 mg kg R . CN 11 ß -l 1 17 21 -trihydroxypregn-4-ene-3 20-dione Reichstein s substance S microbiological hydroxylation Curvuloria lunato Hydrocortisone Hydrocortisone 1022 H Hydrocortisone o cortisone 21-acetate semicorbazide IV hydrochloride 3 3 20 20-bis ethylenedioxy - 110 17 21 -trlhydroxy-5-pregnene from cortisone progesterone Hydrocortisone microbiological hydroxylation Rhizopus arrhizus Fischer ATCC-11145 or Rhizopus nigricans ------------------------------ -------------- 11 a-hydroxy-progesterone V CrOj CHjCOOH 11 -oxoprogesterone 0 H3C O-hAO-CH3 0 NoOC2H5 -------------------- diethyl oxalate VI Hydrocortisone H 1023 VIH H2O2 0s04 cr ------ ---------- K N-methyl- morpholine hydrocortisone 21-acetóte IX Reference s a US 2 649 401 Upjohn 1953 appl. 1950 . US 2 658 023 Pfizer 1953 appl. 1952 . US 2 794 816 Upjohn 1957 appl. 1954 . synthesis o cortexolon Julian PL. J. Am. Chem. Soc. JACSAT 72 5145 1950 . Sondheimer F. et al. J. Am. Chem. Soc. JACSAT 78 816 1956 . The Merck Index 2891 Rahway 1976 . b Oliveto E. et al. J. Am. Chem. Soc. JACSAT 78 1736 1956 . c US 2 666 069 American Cyanamid 1954 appl. 1951 . synthesis of starting material US 2 622 081 American Cyanamid 1952 appl. 1951 . US 2700 666 American Cyanamid 1955 appl. 1953 . d Hogg . et al. J. Am. Chem. Soc. JACSAT 77 4436 1955 . US 2 769 823 Upjohn 1956 appl. 1954 . alternative syntheses US2541 104 Merck Co. 1951 appl. 1947 . GB 800 797 Pfizer appl. 1956 USA-prior. 1955 . US4041 055 Upjohn appl. . DOS 2 803 660 Schering AG appl. . DOS 2 803 661 Schering AG appl. . review Fieser . Fieser M.

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