TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 99

Pharmaceutical Substances Syntheses, Patents, Applications - Part 99. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Griseofulvin G 981 Griseofulvin ATC D01AA08 D01BA01 Use antifungal antibiotic RN 126-07-8 MF CI7H17C1O6 MW EINECS 204-767-4 LD50 280 mg kg M . 50 g kg M . 400 mg kg R . 10 g kg R . CN rS-tran5 -7-chloro-2 4 6-trimethoxy-6 -methylspiro benzofuran-2 3 r- 2 cyclohexene dione From fermentation solutions of Pénicillium patuluin. Reference s GB 784 618 Glaxo appl. . US 2 900 304 ICI GB-prior. . US 3 038 839 Glaxo GB-prior. . US 3 069 328 Glaxo GB-prior. . US 3 069 329 Glaxo GB-prior 4 5 1960 pharmaceutical formulation with polyethyleneglycol US 4 151 273 Univ of California prior. . total syntheses Brossi A. et al. Helv. Chim. Acta HCACAV 43 1444 1960 . Day . et al. Proc. Chem. Soc. London PCSLAW 1960 284. Kuo . et al. Chem. Ind. London CHINAG 1960 1627. Stork G. et al J. Am. Chem. Soc. JACSAT 84 310 1962 . Formulation s cps. 125 mg 250 mg cream 5 g 100 g tabl. 125 mg 165 mg 330 mg 500 mg Trade Name s D Fulcin S Zeneca Griséfuline Sanofi Grisetin Nippon Kayaku Gricin Creme LAW Winthrop Grisovin Fujisawa Gricin Tabl. ASTA Medica GB AWD Fulcin Zeneca Grisovin Glaxo Wellcome Guservin Chugai USA Fulvicin P G Schering griseco ct-Arzneimittel I Likuden M Hoechst Fulcin SIT Griseofulvina Scfm Grifulvin V Ortho Dermatological F Fulcine Zeneca Pharma J Grisovina Fp Teofarma Grifulvin Yamanouchi Grisactin Wyeth-Ayerst Gris-PEG Allergan Guaiazulene Guajazulene ATC S01XA01 Use anti-inflammatory RN 489-84-9 MF C15H18 MW EINECS 207-701-2 LD50 1220 mg kg M . 1550 mg kg R . CN 1 4-dimethyl-7 - 1 -methylethy l azulene G 982 Guaifenesin guaiol constituent of guaiocum wood oil guaiene Reference s CH 314 487 Dr. B. Joos appl. 1953 . Formulation s cream drg. 20 mg ointment ethanolic camomile extract Trade Name s D Azulon Kamillen Creme ASTA Medica AWD Azupanthenol Parke Davis -comb. Garmastan Protina Thrombocid .

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