TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 150

Pharmaceutical Substances Syntheses, Patents, Applications - Part 150. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Opipramol o 1491 Trade Name s D Zofran Glaxo Wellcome GB Zofran Glaxo Wellcome J Zofran Glaxo-Sankyo F Zophren Glaxo Wellcome 1991 Sankyo 1 Zofran Glaxo Wellcome USA Zofran Glaxo Wellcome Opipramol ATC N06AA05 Use thymoleptic antidepressant RN 315-72-0 MF C23HMN3O MW EINECS 206-254-0 LD50 45 mg kg M . 400 mg kg M . 32 mg kg R . 1110 mg kg R . CN 4- 3- 5 -dibenz azepin-5-yl propyl -l-piperazineethanol dihydrochloride RN 909-39-7 MF C23H29N3O 2HC1 MW EINECS 213-000-2 LDS0 45 mg kg M . 443 mg kg M . 32 mg kg R . 900 mg kg R . 1. NoNH2 2. Br CI ------------------- 1. sodium omide 2. 1 -bromo-3-chloro- propone 5- 3-chloropropyl -5H- 2-piperazinoethonol dibenz b f ozepine I Reference s GB 862 297 Geigy appl. CH-prior. . FR 1 271 971 Geigy appl. CH-prior. . GB 881 398 Rhône-Poulenc appl. valid from . DE 1 132 556 Geigy appl. CH-prior. . DE 1 133 729 Geigy appl. CH-prior. . Formulation s drg. 50 mg as dihydrochloride Trade Name s D Insidon Novartis Pharma I F Insidon Novartis J GB Insidon Geigy wfm Insidon Novartis Farma Insidon Geigy-Fujisawa USA Ensidon Ciba-Geigy wfm Orazamide AICA-Orotate ATC A05B Use liver therapeutic RN 2574-78-9 MF C5H4N2O4 C4H6N4O MW EINECS 219-923-7 LD5i 600 mg kg M . CN 5-amino-l 7-imidazole-4-carboxamide orotate 1 1 1492 O Orciprenaline 4-ominoimidozole-5- corboxamide hydrochloride sodium oratote Orazomide Reference s GB 1 018 117 Fujisawa appl. J-prior. . US 3 271 398 Fujisawa J-prior. . newer method for AICA DE 2 160 674 Sagami appl. J-prior. . Formulationfs tabl. 100 mg Trade Name s D Aicorat Mack liiert. F Aicamine Labaz wfm wfm I Aicamin Crinos wfm J Aicamin Fujisawa Orciprenaline Metaproterenol ATC R03AB03 R03CB03 Use bronchodilator antiasthmatic RN 586-06-1 MF CuHjyNOj MW EINECS 209-569-1 LD5 86 mg kg M . 8130 mg kg M . .

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