TAILIEUCHUNG - CLINICAL PHARMACOLOGY 2003 (PART 25B)

Overdose, including self-poisoning, causes bradycardia, heart block, hypotension and low output cardiac failure that can proceed to cardiogenic shock; death is more likely with agents having membrane stabilising action (see Table ). Bronchoconstriction can be severe, even fatal, in patients subject to any bronchospastic disease; loss of consciousness may occur with lipid-soluble agents that penetrate the central nervous system. Receptor blockade will outlast the persistence of the drug in the plasma. Rational treatment includes: • Atropine (1-2 mg . as 1 or 2 bolus doses) to eliminate the unopposed vagal activity that contributes to bradycardia. Most patients will also. | Overdose Overdose including self-poisoning causes bradycardia heart block hypotension and low output cardiac failure that can proceed to cardiogenic shock death is more likely with agents having membrane stabilising action see Table . Bronchoconstriction can be severe even fatal in patients subject to any bronchospastic disease loss of consciousness may occur with lipid-soluble agents that penetrate the central nervous system. Receptor blockade will outlast the persistence of the drug in the plasma. Rational treatment includes Atropine 1-2 mg . as 1 or 2 bolus doses to eliminate the unopposed vagal activity that contributes to bradycardia. Most patients will also require direct cardiac pacing. 20 Practolol was developed to the highest current scientific standards it was marketed 1970 as the first cardioselective p-blocker and only after independent review by the UK drug regulatory body. All seemed to go well for about 4 years though skin rashes were observed by which time there had accumulated about 200 000 patient years of experience with the drug and then wrote the then Research Director of the industrial developer came a bolt from the blue and we learnt that it could produce in a small proportion of patients a most bizarre syndrome which could embrace the skin eyes inner ear and the peritoneal cavity and also the lung oculomucocutaneous syndrome . The cause is likely to be an immunological process to which a small minority of patients are prone with present knowledge we cannot say it will not happen again with another drug . That the drug caused this peculiar syndrome was recognised by an alert opthalmologist who ran a special clinic for external eye diseases. In 1974 he suddenly became aware that he was seeing patients complaining of dry eyes but with unusual features. Instead of the damage blood vessel changes with metaplasia and kératinisation of the conjunctive being on the front of the eye exposed by the open lids it was initially in the areas .

• Y học thường thức
• Overdose
• clinical pharmacology
• sách học ngành dược
• dược lý lâm sàng
• tài liệu học dược sĩ
• bảo quản thuốc
• thuốc trị bệnh
• bào chế thuốc
• BMC Pharmacology and Toxicology
• Ibuprofen overdose
• Therapeutic plasma exchange
• Tissue specific complications of poisoning
• Ibuprofen plasma concentration
• Poisoning
• antidotes
• báo cáo khoa học
• báo cáo y học
• công trình nghiên cứu về y học
• tài liệu về y học
• cách trình bày báo cáo
• Infectious & tropical diseases
• Respiratory medicine
• Poisoning and overdose
• Southampton University Hospitals
• Consultant in Nuclear Medicine
• Consultant Senior Lecturer in Medicine
• trình bày báo cáo
• tài liệu báo cáo khoa học
• kiến thức y học
• nghiên cứu y học
• báo cáo hóa học
• công trình nghiên cứu về hóa học
• tài liệu về hóa học
• giáo trình y học
• dược học đại cương
• tài liệu y khoa
• hướng dẫn học y khoa
• kiến thức y khoa
• điều trị bệnh
• báo cáo toán học
• tài liệu báo cáo nghiên cứu khoa học
• kiến thức toán học
• các báo cáo toán học hay
• công trình y học