TAILIEUCHUNG - CLINICAL PHARMACOLOGY 2003 (PART 5)

Preclinical drug development. Discovery of new drugs in the laboratory is an exercise in prediction • Techniques of discovery. Sophisticated molecular modelling allows precise design of potential new therapeutic substances and new technologies have increased the rate of development of potential medicines. Studies in animals and in humans Prediction. Failures of prediction occur and a drug may be abandoned at any stage, including after marketing. New drug development is a colossally expensive and commercially driven activity. . | 3 SECTION I Discovery and development of drugs SYNOPSIS Preclinical drug development. Discovery of new drugs in the laboratory is an exercise in prediction Techniques of discovery. Sophisticated molecular modelling allows precise design of potential new therapeutic substances and new technologies have increased the rate of development of potential medicines. Studies in animals and in humans Prediction. Failures of prediction occur and a drug may be abandoned at any stage including after marketing. New drug development is a colossally expensive and commercially driven activity. Orphan drugs and diseases. Preclinical drug development Pharmacology and medicinal chemistry have transformed medicine from an intellectual exercise in diagnosis into a powerful force for the relief of human disease CT Dollery 1994 The development of new medicines drugs is an exercise in prediction from laboratory studies in vitro and in vivo animals which forecast what the agent will do to man. Medicinal therapeutics rests on the two great supporting pillars of pharmacology Selectivity the desired effect alone is obtained We must learn to aim learn to aim with chemical substances Paul Ehrlich .1 2 Dose . .The dose alone decides that something is no poison Paracelsus .3 For decades the rational discovery of new medicines has depended on modifications of the molecular structures of increasing numbers of known natural chemical mediators. Often the exact molecular basis of drug action is unknown and this book contains frequent examples of old drugs whose 1 In this chapter we are grateful for permission from Professor Sir Colin Dollery to quote directly and indirectly from his Harveian Oration Medicine and the pharmacological revolution 1994 Journal of the Royal College of Physicians of London 28 59-69. 2 Paul Ehrlich 1845-1915 German scientist who pioneered the scientific approach to drug discovery. The 606th organic arsenical that he tested against spirochaetes in animals became a successful .

• Y học thường thức
• development of drugs
• clinical pharmacology
• sách học ngành dược
• dược lý lâm sàng
• tài liệu học dược sĩ
• bảo quản thuốc
• thuốc trị bệnh
• bào chế thuốc
• Illustrated pharmacology for nurse
• Drug development
• Classification and nomenclature of drugs
• Pharmacodynamics of drugs
• Pharmacokinetics of drugs
• Adverse effects of drugs
• Drug interactions
• Pluronic – grafted copolymers
• Grafted copolymers as nanoplatforms
• Effectively delivering hydrophobic anticancer drugs
• Innovative development
• tài liệu sinh học
• tài liệu tiếng anh
• chất ức chế
• Enzyme
• phản ứng Enzyme
• trình bày báo cáo
• tài liệu báo cáo khoa học
• báo cáo y học
• kiến thức y học
• nghiên cứu y học
• Antimicrobial Drugs
• Glycopeptide Resistance
• Antibacterial Agents
• Aminoglycosides
• Empiricism Ruled
• Antibiotic Discovery
• Information technology
• acquire knowledge
• Severe Ulcerative Colitis
• Drug Therapy
• Biologic Drugs
• Ulcerative Colitis
• Immunodeficiency virus
• Several studies
• antiretroviral drugs
• significantly higher
• previous history
• Tuberculosis
• Cardiovascular pharmacotherapeutics
• Complementarymedicine for preventing
• Treatingcardiovascular disease
• Cardiovascular drug–drug interactions
• Drug treatment of peripheral vascular disorders
• Cardiovascular drugs in development
• Pediatric cardiovascular pharmacology
• HIV infected
• clinically
• immune dysfunction
• Manual of botulinum toxin therapy
• The pretherapeutic history
• Botulinum toxin
• History of clinical development
• Botulinum toxin drugs
• Ttreatment of hemifacial spasm
• BMC Cancer
• Colorectal cancer
• Gastrointestinal safety
• Non steroidal anti inflammatory drugs
• Gastro intestinal
• NSAID sulindac
• BMC Pulmonary medicine
• Diabetes mellitus
• Anti diabetic drugs
• Cox proportional hazard regression models
• Mycobacterium tuberculosis
• BMC Geriatrics
• Systematic review
• Benzodiazepine like medication
• Z drugs
• Inappropriate prescribing
• Older people
• Candidate Drugs
• Toxicity of Microcystins
• Herbal Medicines
• Potential Toxicities
• Animal Models
• Cell based assay system
• DNA methylation
• Rapid screening bioassay
• Epigenetic drug model
• PEGylated liposomes
• Chromatography A
• Mixed mode zwitterionic sorbents
• Silica sorbents
• Environmental samples
• Solid phase extraction
• Basic compounds
• current guidelines
• recommend treatment
• symptomatic HIV
• antiretroviral treatment
• TB incidence
• Public health
• Substance use
• College students
• Health compromising behaviors
• Misused prescription drugs