TAILIEUCHUNG - Roles of extended human papillomavirus genotyping and multiple infections in early detection of cervical precancer and cancer and HPV vaccination

The aim of the study was to investigate the risk of human papillomavirus (HPV) genotyping particularly vaccine genotypes and multiple infections for cervical precancer and cancer, which might contribute to developing genotype-specific screening strategy and assessing potential effects of HPV vaccine. | Song et al. BMC Cancer 2022 22 42 https s12885-021-09126-3 RESEARCH Open Access Roles of extended human papillomavirus genotyping and multiple infections in early detection of cervical precancer and cancer and HPV vaccination Fangbin Song1 2 3 Peisha Yan1 2 3 Xia Huang1 2 3 Chun Wang1 2 3 Hui Du1 2 3 Xinfeng Qu4 and Ruifang Wu1 2 3 Abstract Background The aim of the study was to investigate the risk of human papillomavirus HPV genotyping particularly vaccine genotypes and multiple infections for cervical precancer and cancer which might contribute to developing genotype-specific screening strategy and assessing potential effects of HPV vaccine. Methods The HPV genotypes were identified using the Seq HPV assay on self-collected samples. Hierarchical rank- ing of each genotype was performed according to positive predictive value PPV for cervical intraepithelial neoplasia 2 3 or worse CIN2 CIN3 . Multivariate logistic regression model was used to estimate the odds ratios ORs with 95 confidence interval CI of CIN2 according to multiplicity of types and vaccine types. Results A total of 2811 HPV-positive women were analyzed. The five dominant HPV genotypes in high-grade lesions were 16 58 52 33 18. The overall ranking orders were HPV16 33 35 58 31 68 18 56 52 66 51 59 45 39 for CIN2 and HPV16 33 31 58 45 66 52 18 35 56 51 68 59 39 for CIN3 . The risks of single infection versus co-infections with other types lower in the hierarchy having CIN2 were not statistically significant for HPV16 multiple infection vs. single infection OR 95 CI P or other genotypes P gt after conservative Bonferroni correction. Whether HPV16 was present or not the risks of single infection versus multiple infection with any number 2 2 or 3 of types for CIN2 were not significantly different. In addition HPV31 33 45 52 58 covered by nonava- lent vaccine added of CIN2 of CIN3 and of cancer to the HPV16 18 genotyping. These genotype- groups .

• Y khoa - Dược
• BMC Cancer
• Human papillomavirus
• Cervical intraepithelial neoplasia
• Cervical cancer
• Genotyping particularly vaccine genotypes
• Cancer patient pathways
• Colorectal cancer
• Lung cancer
• Breast cancer
• Prostate cancer
• Ovarian cancer
• Cancer detection
• Ovarian cancer symptoms
• Ovarian cancer signs
• Ovarian cancer tests
• Cancer biomarkers
• Pediatric cancer
• Familial cancer predisposition
• Hereditary cancer syndrome
• Genetic cancer susceptibility
• Advanced cancer
• Biliary tract cancer
• Multimodal intervention
• Pancreatic cancer
• Physical activity
• Breast cancer screening
• Familial breast cancer
• Young breast cancer survivors
• High risk relatives
• Randomized trial
• Childhood cancer
• Childhood cancer survivor
• Thyroid cancer screening
• Secondary cancer
• Cancer screening
• Community awareness
• Cancer education
• Prior cancer
• Cancer survivors
• Cancer registry
• Second cancer
• Surgical oncology
• Cancer imaging
• Radiation oncologists
• Medical oncologists
• Oesophagogastric cancer
• Liver cancer
• Hepatobiliary cancer
• Multidisciplinary rehabilitation
• EGFR mutation
• Family history of cancer
• Inherited susceptibility
• Cancer predisposition genes
• Lung cancer aetiology
• Cancer stem cells
• Oct4 overexpressing lung cancer
• Human lung cancer xenograft model
• Disease free survivals
• Cancer hallmarks
• Cancer genesis
• Defiant disease
• Mutational signature
• Cancer diagnosis
• Cancer genomics
• Molecular medicine
• Whole genome sequencing
• Cancer susceptibility gene
• Breast cancer prognosis
• Next generation sequencing
• Quality of care
• Quality indicators
• Shifting cancer care
• German cancer society
• Colorectal cancer screening
• Stomach cancer screening
• Lung cancer survivor
• Physician recommendation
• Total number of lymph nodes
• Lymph node ratio
• Left colon cancer
• Right colon cancer
• Overall survival
• Cumulative incidence
• Esophageal cancer
• Head and neck cancer
• Metachronous cancer
• Young onset
• Reproductive cancer
• Risk factor
• Early detection of cancer
• Gastric cancer incidence
• Population based specialized registry
• Gastric cancer survival
• Gastric cancer clinical characteristics
• Gastric cancer pathological characteristics
• Lung Cancer Screening
• Racial disparities
• Lung Cancer diagnosis
• Screening adherence
• Second primary colorectal cancer
• Standardized incidence ratio
• Left sided colon cancer
• Right sided colon cancer
• Quality of cancer care
• Population based study