TAILIEUCHUNG - Factors associated with response to compression-based physical therapy for secondary lower limb lymphedema after gynecologic cancer treatment: A multicenter retrospective study

Lower limb lymphedema (LLL) is one of the most refractory and debilitating complications related to gynecological cancer treatment. We investigated factors associated with response to compression-based physical therapy (CPT) for secondary LLL after gynecologic cancer treatment. | Yoshihara et al. BMC Cancer 2022 22 25 https s12885-021-09163-y RESEARCH Open Access Factors associated with response to compression based physical therapy for secondary lower limb lymphedema after gynecologic cancer treatment a multicenter retrospective study Masato Yoshihara1 2 Kaoru Kitamura3 Satoko Tsuru4 Ryoko Shimono5 Hiromi Sakuda6 Michinori Mayama2 7 Sho Tano1 2 Kaname Uno1 2 Mayu Ohno Ukai1 2 Yasuyuki Kishigami2 Hidenori Oguchi2 and Akio Hirota8 Abstract Background Lower limb lymphedema LLL is one of the most refractory and debilitating complications related to gynecological cancer treatment. We investigated factors associated with response to compression-based physical therapy CPT for secondary LLL after gynecologic cancer treatment. Methods We performed a multicenter retrospective study using the records of seven medical institutions from 2002 and 2014. Patients who developed LLL after gynecological cancer treatment were included. Limb volumes were calculated from the lengths of the limb circumferences at four points. All participants underwent compression-based physical therapy for LLL. Factors including MLD indicative of circumference reductions in LLL were determined. Results In total 1 034 LLL met the required criteria of for the study. A multivariate linear regression analysis identified age body mass index BMI endometrial cancer radiotherapy and initial limb circumference as significant independ- ent prognostic factors related to improvement in LLL. In analysis of covariance for improvement in LLL adjusted by the initial limb circumference and stratified by BMI and radiotherapy patients with BMI 28 kg m2 or higher and receiving radiation rarely responded to CPT. Conclusions Improvements in the lower limb circumference correlated with clinical histories and physical charac- teristics which may be used as independent prognostic factors for successful CPT for LLL after gynecological cancer treatment. Keywords Lymphedema Gynecologic .

• Y khoa - Dược
• BMC Cancer
• Gynecologic neoplasms
• Compression bandage
• Lower limb lymphedema
• Compression based physical therapy
• Cancer patient pathways
• Colorectal cancer
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