TAILIEUCHUNG - Crosstalk between autophagy and DNA repair systems

Autophagy and DNA repair are two essential biological mechanisms that maintain cellular homeostasis. Impairment of these mechanisms was associated with several pathologies such as premature aging, neurodegenerative diseases, and cancer. Intrinsic or extrinsic stress stimuli (., reactive oxygen species or ionizing radiation) cause DNA damage. As a biological stress response, autophagy is activated following insults that threaten DNA integrity. Hence, in collaboration with DNA damage repair and response mechanisms, autophagy contributes to the maintenance of genomic stability and integrity. Yet, connections and interactions between these two systems are not fully understood. In this review article, current status of the associations and crosstalk between autophagy and DNA repair systems is documented and discussed. | Turkish Journal of Biology Turk J Biol 2021 45 235-252 http biology TÜBİTAK Review Article doi biy-2103-51 Crosstalk between autophagy and DNA repair systems 1 1 1 2 3 3 Sinem DEMİRBAĞ-SARIKAYA Hatice ÇAKIR Devrim GÖZÜAÇIK Yunus AKKOÇ 1 SUNUM Nanotechnology Research and Application Center İstanbul Turkey 2 Koç University School of Medicine İstanbul Turkey 3 Koç University Research Center for Translational Medicine KUTTAM İstanbul Turkey Received Accepted Published Online Final Version Abstract Autophagy and DNA repair are two essential biological mechanisms that maintain cellular homeostasis. Impairment of these mechanisms was associated with several pathologies such as premature aging neurodegenerative diseases and cancer. Intrinsic or extrinsic stress stimuli . reactive oxygen species or ionizing radiation cause DNA damage. As a biological stress response autophagy is activated following insults that threaten DNA integrity. Hence in collaboration with DNA damage repair and response mechanisms autophagy contributes to the maintenance of genomic stability and integrity. Yet connections and interactions between these two systems are not fully understood. In this review article current status of the associations and crosstalk between autophagy and DNA repair systems is documented and discussed. Key words Autophagy DNA damage DDR DNA repair 1. Introduction cause loss of genetic information and even trigger genomic Maintenance of cellular homeostasis in living organisms instability and rearrangements. Fortunately in healthy requires a balance between anabolic and catabolic individuals most of these lesions are repaired by the reactions. Various endogenous and exogenous insults lead activation of DNA damage response DDR and following to the activation of cellular and organismal stress response DNA damage repair mechanisms. Although autophagic mechanisms. Macroautophagy autophagy herein is one machinery

• Sinh học
• Journal of Biology
• DNA damage
• DNA repair
• Biological mechanisms
• Cellular homeostasis
• Ionizing radiation
• Schizosaccharomyces pombe
• Mechanistic toxicology
• Cell biology
• Autophagy deficient cells
• Autophagosome formation
• Journal of Botany
• CRISPR/Cas9 system
• Model plants
• Plant biology
• Zinc finger nucleases
• Transcription activatorlike effector nucleases
• Large scale genetic screens
• Journal of Vietnam Agricultural Science and Technology
• Tạp chí Khoa học Công nghệ Nông nghiệp Việt Nam
• Piper nigrum
• Flower biology
• Anther dehiscence
• Stigma receptivity
• Turkish Journal of Biology
• Tạp chí Sinh học
• Doxorubicin induced transcriptome
• Systems biology
• DNA double strand breaks
• Reactive oxygen species
• báo cáo khoa học
• báo cáo hóa học
• công trình nghiên cứu về hóa học
• tài liệu về hóa học
• cách trình bày báo cáo
• trình bày báo cáo
• tài liệu báo cáo khoa học
• báo cáo y học
• kiến thức y học
• nghiên cứu y học
• Báo cáo sinh học hay
• báo cáo sinh học
• công trình nghiên cứu sinh học
• tài liệu về sinh học
• Quantitative Paleozoology
• Vertebrate Taphonomy
• Modern Ecological
• Conservation Biology
• biogeographic dynamics
• archaeological deposits
• Bài báo khoa học
• Academia Journal of Biology
• Động vật phù du
• Loài giáp xác râu
• Loài Grimaldina brazzai Richard
• Nuôi cấy sơ cấp
• Nuôi cấy tế bào
• Nguyên bào sợi
• Hiệu giá kháng thể
• Kháng thể đơn dòng kháng A
• Nhóm máu A
• Nhóm máu AB
• Tế bào lai
• Coptotermes gestroi
• DNA metagenome
• Endo 1 4 xylanase
• Glycoside hydrolase
• Nannochloropsis oculata
• Navicula tuscula
• Fatty acid
• Trachypithecus germaini
• Voọc bạc đông dương
• Núi đá vôi
• Thành phần loài
• Thảm thực vật
• New records of snakes
• Huu Lien nature reserve
• Reptile collection
• Cá ngựa vằn
• Phôi cá ngựa vằn
• Nhịp quẫy mình
• Danio rerio
• 16S rDNA
• Phylogenetic analyses
• Diversity of microcystins
• Non microcystin producing Microcystics population
• Protein chitinase
• Phương pháp bề mặt đáp ứng
• Sản xuất chitinase
• Tối ưu điều kiện biểu hiện
• Garcinia mangostana
• Độc tính tế bào
• Tế bào ung thư
• Cải biến gen
• Cây thuốc lá
• Gen cải biến gdhA
• Cây thuốc lá Nicotiana tabacum
• Gen độc lực
• Biểu hiện gen độc
• Chủng Salmonella
• Ngộ độc thực phẩm