TAILIEUCHUNG - Synthesis, structure and anticancer activity of two platinacyclic complexes bearing isopropyl eugenoxyacetate and pyridine derivatives

The results show the iPrEug coordinates with Pt(II) through ethylenic double bond of the allyl group and C5 of the benzene ring, while the amines only coordinate with Pt(II) via the N heteroatom and occupy cis-position in comparison with the allyl group. | HNUE JOURNAL OF SCIENCE DOI Natural Sciences 2018 Volume 63 Issue 11 pp. 103-109 This paper is available online at http SYNTHESIS STRUCTURE AND ANTICANCER ACTIVITY OF TWO PLATINACYCLIC COMPLEXES BEARING ISOPROPYL EUGENOXYACETATE AND PYRIDINE DERIVATIVES Nguyen Trong Nhan1 Truong Thi Cam Mai1 and Nguyen Thi Thanh Chi2 1 Department of Chemistry Quy Nhon University 2 Faculty of Chemistry Hanoi National University of Education Abstract. Reaction of the dinuclear chelate ring complex Pt μ-Cl iPrEug 2 1 iPrEug deprotonated isopropyl eugenoxyacetate with either 2-aminopyridine PyNH2 or 2 2 - bipyridine N-oxide PyO afforded two mixed olefin-amine complexes namely PtCl iPrEug PyNH2 2 or PtCl iPrEug PyO 3 with the high yield 85 90 . The structures of 2 and 3 were elucidated by weight method ESI-MS IR and 1H NMR spectroscopies. The results show the iPrEug coordinates with Pt II through ethylenic double bond of the allyl group and C5 of the benzene ring while the amines only coordinate with Pt II via the N heteroatom and occupy cis-position in comparison with the allyl group. Complexes 2 and 3 exhibit cytotoxic activities against KB and Hep-G2 cancer cell lines with the IC50 values of μg ml. Keywords Isopropyl eugenoxyacetate Pt II complexes pyridine derivatives anticancer activity. 1. Introduction Platinum-based drugs notably cisplatin carboplatin and oxaliplatin have dominated the treatment of various cancers by chemical agents. However these drugs cause serious side effects hence unconventional platinum II complexes with different organic ligands were designed as a strategy to overcome the side effects and resistance to cisplatin and its analogs. 1-3 Some complexes of platinum II with natural compounds have been synthesized and demonstrated their antitumor activities. 3 Beside medical purpose Pt and its complexes are known for essential roles in organic synthesis especially many Pt-olefin complexes are intermediates

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