TAILIEUCHUNG - Facile multi-components one-pot synthesis of dipyrazolo[1,5-a:3',4'-d]pyrimidine as potent bioactive scaffolds

An efficient, three-component, catalyst free synthesis of dipyrazolo[1,5-a:3',4'-d]pyramid scaffolds has been carried out using 3-methyl-1H-pyrazol-5(4H)-one (1), 5-amino pyarazole (2a-b) and substituted aromatic aldehydes. | Facile multi-components one-pot synthesis of dipyrazolo 1 5-a 3 4 -d pyrimidine as potent bioactive scaffolds Current Chemistry Letters 7 2018 111 120 Contents lists available at GrowingScience Current Chemistry Letters homepage Facile multi-components one-pot synthesis of dipyrazolo 1 5-a 3 4 -d pyrimidine as potent bioactive scaffolds Ravindra M. Gola and Vijaykumar M. Barota a P. G. Center in Chemistry Smt. S. M. Panchal Science College Talod Gujarat India CHRONICLE ABSTRACT Article history An efficient three-component catalyst free synthesis of dipyrazolo 1 5-a 3 4 -d pyramid Received June 20 2018 scaffolds has been carried out using 3-methyl-1H-pyrazol-5 4H -one 1 5-amino pyarazole Received in revised form 2a-b and substituted aromatic aldehydes. The reaction underwent cyclocondensation reaction August 27 2018 in reflux condition with moderate to good 62 90 yields. The twenty newly prepared Accepted October 30 2018 molecules were analyzed by means of 1H amp 13C NMR Mass and IR spectroscopies and their Available online activities against the bacterial and fungal strains were screened. Some of tested compounds October 30 2018 have shown excellent antibacterial activities while another four were found to have good Keywords antifungal activity. Dipyrazolo 1 5-a 3 4 - d pyrimidine Multi-component reaction Catalyst free Antibacterial Antifungal 2018 by the authors licensee Growing Science Canada. 1. Introduction Pyrimidine scaffold is found in several naturally occurring compounds and they make the core structures of many biologically active scaffolds and much more pharmaceutical industrial 2 For the most part significant fused dipyrazoloes is diprazolopyrimidine derivative which acquires a range of biological potent The MCRs Multi-components reaction approach is more convenient in comparison to conventional synthesis because of flexibility and atom-efficient We used the MCRs for an optimization of a .

• Hoá học
• Multi component reaction
• Catalyst free synthesis
• Substituted aromatic aldehydes
• Underwent cyclocondensation reaction
• Pharmaceutical industrial materials
• Knoevenagel condensation reaction
• KOH loaded CaO
• 4H pyran derivatives
• One pot multicomponent reaction
• Solvent free condition
• Journal of Chemistry
• Guanidinium salt
• Multicomponent reaction
• Guanidine containing heterocycles
• 2 aminopyrimidine compounds
• Organic salts
• 2 hydroxy 1 4 naphthoquinone
• Crystal structure
• Hydrogen bonds
• Tạp chí khoa học
• Khoa học tự nhiên
• Mannich reaction
• Multicomponent condensation reaction
• Azacrown ether
• Natural sciences
• Aldehyde alkyne amine
• Solvent free
• Metal free
• Methods and reagents for green chemistry
• Green chemistry
• The Four Component reaction
• Other multicomponent reactions
• Dimethyl carbon
• Ultrasound accelerated arylthiomethylation
• Mannich type reactions
• Magnetic stirring and ultrasonic irradiation
• The mechanism and process
• Mannich type reactions in the synthesis
• Transition metal
• Periodic table
• Coordination compounds
• Biomedical industry
• N bromosuccinimde catalyzed
• One pot condensation
• One pot multicomponent condensation reaction
• By product N succinimide
• Environmentally benign chemical processe
• Functionalized tetrahydropyridine
• Condensed tetrahydropyridine
• Tryptamine receptor agonist
• Muscarinic receptor agonist
• 3 Amino 9 ethylcarbazole
• Arylation reactions
• Cyclization reactions
• Pyrrolo[2 3 c]carbazole
• Prido[3 2 b]carbazole
• Antitumor activity
• Mannich base
• Green synthesis
• Methylene tethered tetrahydroquinolines
• 6 aryl 3 oxo 2
• 3 dihydropyridazine 4 carbohydrazide derivatives
• Diversity oriented construction
• 6 arylpyridazinone skeleton
• Multicomponent reactions
• 1 3 4 oxadiazoles
• Trichloroacetyl isocyanate
• (N isocyanimino)triphenylphosphorane
• Aza Wittig
• Cyclic enaminones
• α β unsaturated nitriles
• Spirooxindole derivatives
• Hexahydroquinoline derivatives