TAILIEUCHUNG - Rising problem of resistant gram negative pathogens in tertiary care setup and susceptibility analysis of Beta lactams and Beta lactam + Beta lactamase inhibitor combinations

Antibiotic resistance has risen perilously in all parts of the world. The lack of appropriate therapeutics to encounter resistant pathogens has enhanced the urge for the development of either new antibiotics or different therapeutic combinations. Hence, this study was aimed to evaluate the antimicrobial efficacy of cefepime plus sulbactam in comparison with cefepime alone and other therapeutics such as third generation cephalosporin (ceftazidime), β-lactam and β-lactamase inhibitor combinations (pipercaillin + tazobactam and cefoperazone + sulbactam) and carbapenem drugs (imepenem and meropenem. The present study was a prospective study conducted over a period of five months (January 2019 – May 2019) in the Department of Microbiology, Grecian Super Speciality Hospital, Mohali (Punjab, India). This study included clinical isolates obtained from clinical specimens collected from outdoor and indoor patients. Antibiotic susceptibility testing was executed in accordance with the recommendations of Clinical Laboratory Standards Institute (CLSI) guidelines. Out of 751 collected specimens, urine specimens contributed followed by blood (), endotracheal secretions (), sputum (), pus (), bronchoalveolar lavage (BAL) (), wound swab (), body fluids () and CSF (). Escherichia coli were found most prevalent () pathogen along with , and prevalence of Pseudomonas aeruginosa, Klebsiella penumoniae and Acinetobacter baumannii respectively whereas rest presence of other pathogens (Providencia spp., Proteus spp., Morganella morganii and Citrobacter spp.) was also observed. The in-vitro antibacterial activity revealed that cefepime + sulbactam () was more active than cefepime alone. | Rising problem of resistant gram negative pathogens in tertiary care setup and susceptibility analysis of Beta lactams and Beta lactam + Beta lactamase inhibitor combinations

• Y khoa - Dược
• Clinical isolates
• Beta lactamase inhibitor combinations
• Beta lactams and Beta lactam
• Resistant gram negative pathogens
• Susceptibility analysis
• Speciation and characterization
• Candida species in clinical isolates
• Predisposing conditions for candidiasis
• Various clinical samples
• Antibiotic susceptibility
• Neonatal septicemia
• Clinical isolates of neonatal septicemia
• Antibiotic susceptibility pattern
• Pseudomonas aeruginosa
• Antibiotic resistance
• Beta lactamase
• Producing clinical isolates
• Biofilm detection
• Prevalence of MRSA
• MRSA and biofilm associated gene
• Biofilm associated gene
• Clinical isolates of staphylococci
• Investigation of antibiofilm potential
• Antibiofilm potential
• Argemone Mexicana
• Calotropis Gigantea against clinical isolates
• Against clinical isolates
• Panton valentine leukocidin gene
• Staphylococcus aureus
• Rapid detection
• Staphylococcus aureus clinical isolates
• Clinical isolates of staphylococcus aureus
• Tertiary care hospital
• Prevalence of MRSA among clinical isolates
• Candida isolates
• Speciation of candida isolates
• Clinical samples
• Conventional and chromagar method
• Chromagar method
• Bovine mastitis
• Bovine clinical mastitis
• Antibiogram of the isolates
• Isolates in Odisha
• Morphological and biochemical characteristics
• Biotechnology and food sciences
• Serotyping of salmonella isolates
• Salmonella isolates from food matrices
• Clinical specimens from Lebanon
• Multidrug resistant bacteria
• Foodborne diseases
• Antifungal susceptibility
• Antifungal susceptibility testing
• Candida isolates in various clinical samples
• Normal flora of human beings
• Phenotypic detection
• Carbapenem resistance
• Escherichia coli
• Klebsiella isolates obtained
• OprD protein profile
• Pseudomonas Aeruginosa isolates resistant
• Imipenem from patients
• Staphylococcal isolates and Pathogens
• Coagulase negative staphylococcal isolates
• Clinically significant specimens
• Resistance of these organisms
• Clinical specimens
• Sub clinical mastitis
• Antibiogram of bacterial isolates
• Bacterial isolates
• Bubaline subclinical mastitis
• Identification of bacterial pathogens
• Dexamethasone abrogates
• Antibiofilm activities
• Different drugs against clinical isolates
• Inducible resistance
• Detection of inducible clindamycin resistance
• Erythromycin in clinical isolates
• Prevalence among methicillin resistant
• Stenotrophomonas maltophilia
• Drug resistance
• Co trimoxazole resistance
• Susceptibility to co trimoxazole
• Honey lemon juice mixtures
• In vitro
• Antimicrobial activity
• Bamenda Cameroon
• Respiratory tract infections
• Vancomycin resistant Enterococci
• Entero cocci fecalis
• Various clinical sample isolates
• Multidrug resistance exhibited
• Serious life threatening VRE infections
• Piperacillin Tazobactum
• Detection and characterization
• Extended spectrum β lactamases
• Salmonella isolates of meat
• Milk and human clinical samples
• Different districts of Chhattisgarh
• Amp C
• Producing enterobacteriaceae isolates
• Extended spectrum beta lactamse
• Multidrug resistance organisms
• Phenotypic detection of MRSA
• Inducible clindamycin resistance
• Staphylococcus study done
• D test positive
• Klebsiella pneumoniae
• ESBL producing Klebsiella pneumoniae
• Antimicrobial susceptibility pattern
• ESBL producing clinical isolates
• Appropriate infection control measures