TAILIEUCHUNG - Network meta-analysis: Users’ guide for pediatricians

Network meta-analysis (NMA) is a powerful analytic tool that allows simultaneous comparison between several management treatment alternatives even when direct comparisons of the alternatives (such as the case in which treatments are compared against placebo and have not been compared against each other) are unavailable. | Al Khalifah et al. BMC Pediatrics 2018 18 180 https s12887-018-1132-9 DEBATE Open Access Network meta-analysis users guide for o pediatricians Reem Al Khalifah1 2 Ivan D. Florez1 3 Gordon Guyatt1 4 and Lehana Thabane1 5 Abstract Background Network meta-analysis NMA is a powerful analytic tool that allows simultaneous comparison between several management treatment alternatives even when direct comparisons of the alternatives such as the case in which treatments are compared against placebo and have not been compared against each other are unavailable. Though there are still a limited number of pediatric NMAs published the rapid increase in NMAs in other areas suggests pediatricians will soon be frequently facing this new form of evidence summary. Discussion Evaluating the NMA evidence requires serial judgments on the creditability of the process of NMA conduct and evidence quality assessment. First clinicians need to evaluate the basic standards applicable to any meta-analysis . comprehensive search duplicate assessment of eligibility risk of bias and data abstraction . Then evaluate specific issues related to NMA including precision transitivity coherence and rankings. Conclusions In this article we discuss how clinicians can evaluate the credibility of NMA methods and how they can make judgments regarding the quality certainty of the evidence. We illustrate the concepts using recent pediatric NMA publications. Keywords Network meta-analysis Multiple treatment comparisons Multiple-treatment meta-analysis evidence synthesis Evidence credibility Evidence certainty Pediatric Background Randomized control trials RCTs constitute the optimal methodology to determine the effectiveness of medical interventions. When results against placebo or standard care suggest benefits outweigh harms clinicians patients and families must choose among several interventions. Making this choice optimally requires access to systematic summaries of the best available .

• Y khoa - Dược
• BMC Pediatrics
• Network meta analysis
• Multiple treatment comparisons
• Multiple treatment meta analysis evidence synthesis
• Evidence credibility
• Evidence certainty
• Acute otitis media
• Primary care pediatrics
• Pneumatic otoscope
• Educational programmes concerning
• National Institutes of Health
• Pediatric integrative medicine
• Healthcare professionals
• Alternative medicine
• Lumbar puncture
• Early onset neonatal sepsis
• American Academy of Pediatrics
• Group B Streptococcus
• 9 Kids’ Inpatient Database
• Public health
• Tasmanian Law Reform Institute
• Non therapeutic circumcision
• Long QT syndrome
• Standing test
• Pediatric emergency department
• Ventricular arrhythmias
• Acute respiratory infection
• Under five years
• Death especially
• Binary logistic regression analysis
• Pediatrics mortality
• Emergency department
• Tikur Anbessa Specialized Tertiary Hosptal
• Neonatal intensive care unit
• RV infection
• Pediatrics guidelines criteria
• Gynecology hospitals
• Demographic data collection
• Electronic health record
• Health care organizations
• Screen viewing
• Psychological wellbeing
• Moderate to vigorous intensity physical activity
• Child abuse pediatrics
• Social risk indicators
• Non social cues
• CAP risk perception
• Not included in the title
• Quality of health care
• Patient satisfaction
• Emergency medical services
• Isolated unilateral temporalis muscle hypertrophy
• IUTMH in pediatrics
• Masticatory muscle hypertrophies
• Visual disturbances
• Pediatrics antiretroviral market
• Pediatric antiretroviral prices
• Global Price Reporting Mechanism
• Price trends
• Pediatric antiretroviral procurement
• Hospitalized children
• Antimicrobial stewardship
• Prescribing antimicrobials
• Discontinuing empiric antimicrobials
• Pediatric tumors
• Infantile orbital tumors
• Isolated enophthalmos
• Orbital tumors
• Care seeking behavior
• Traditional medicine
• National Hospital of Pediatrics
• Neonatal jaundice
• Transcutaneous bilirubin
• Neonatal hyperbilirubinemia
• Especially kernicterus
• Parental decisions regarding immunization
• Knowledge practices
• Immunization rate
• Knowledge practice
• Factors underlying inadequate
• Unvaccinated children
• Epileptic attack
• School absenteeism
• Childhood epilepsy
• Epilepsy in Ethiopia
• Social media
• Infant care
• Anticipatory guidance
• Preschool teachers
• Knowledge retention
• Pediatric first aid
• Ulcerative colitis
• Inflammatory bowel diseases
• Childhood onset Crohn’s disease
• Histopathological examination
• Intestinal spirochetosis
• Brachyspira aalborgi
• Brachyspira pilosicoli
• Inflammatory bowel disease