TAILIEUCHUNG - Role of highly sensitive C- reactive, protein, Interleukin-6 and procalcitonin in early diagnosis of neonatal sepsis

The diagnosis of neonatal sepsis is difficult because clinical manifestation is non-specific. Timely detection and treatment will help in decreasing mortality and morbidity. Blood culture is gold standard but the diagnosis is often retrospective. Thus there is a need for an alternative method which is more rapid, reliable and sensitive. This study was designed to determine the sensitivity, specificity, NPV, PPV and accuracy of hs-CRP, IL-6 and PCT levels, as a diagnostic marker of EONS. 206 neonates with sign and symptoms of sepsis admitted in NICU were included in this study. Blood culture was performed by Bac T/Alert 3D method, hs-CRP, IL-6 and PCT by ELISA. Low birth weight and prematurity were the most common risk factors present in 74% of EOS and 66% of LOS cases. Prolonged IV antibiotics were a risk factor in in EOS and 50% in LOS. CoNS () was the predominant bacterial pathogen isolated, followed by Staphylococcus aureus (), Escherichia coli (), Acinetobacter baumanii () and Klebsiella pneumoniae () in EOS cases. | Role of highly sensitive C- reactive, protein, Interleukin-6 and procalcitonin in early diagnosis of neonatal sepsis

• Sinh học
• Blood culture
• Neonatal sepsis
• Early onset neonatal sepsis
• Late onset neonatal sepsis
• Highly Sensitive C reactive protein
• Blood clot culture
• Comparison of blood clot culture
• Conventional blood culture
• Biphasic blood culture
• Diagnosis of enteric fever
• Bacteriological profile of blood culture
• Adult sepsis patients
• Rural based tertiary care
• Teaching hospital
• BACTEC blood culture system
• Versus conventional blood culture
• Bacteriaemia in pediatric patients
• Pediatric patients
• Early detection
• Antibiotic resistance pattern
• Blood culture isolates
• Creactive protein
• CRP and blood culture
• Diagnosis of neonatal sepsis
• Non albicans Candida
• Antifungal susceptibility
• Prevalence of candida species
• Antifungal susceptibility isolated
• Blood culture at tertiary care hospital
• Blood stream infection
• Bacterial pathogens
• Frequency of bacterial pathogens
• Antibacterial susceptibility pattern
• Isolates from blood culture
• Tertiary care hospital
• BMC Musculoskeletal Disorders
• Periprosthetic joint infection
• Periprosthetic tissue
• Blood culture bottles
• Meta analysis
• Diagnostic performance
• Typhoid fever
• Widal test
• Immunochromatogr aphic test
• Salmonella typhi
• Vancomycin resistant enterococci
• Methicillin resistant staphylococcus aureus
• Gram positive Cocci
• Blood stream infections
• Mango pulp
• Mango peel powder
• Chemical preservative
• Sensory properties
• Their antimicrobial susceptibility pattern
• Blood culture of neonates
• Antibiotic resistant
• Antimicrobial therapy
• Antimicrobial resistance
• Journal of Biology
• Blood–brain barrier
• 3 dimensional cell culture
• Transmembrane resistance
• Central nervous system (CNS)
• Transmembrane resistance (TR)
• BMC Anesthesiology
• Real time multiplex polymerase chain reaction
• Gram negative bacteria
• Candida species
• Fungal infection
• Polymerase chain reaction
• Antifungal therapy
• No bacterial Growth
• Irrational use of antibiotics leading
• No bacterial growth on culture
• Blood agar and MacConkey agar
• Woman Beautiful
• medical books
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• blood infections
• anatomy
• Preventing Morbidity
• Multidisciplinary Care
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• Structural biochemistry
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• báo cáo khoa học
• báo cáo y học
• công trình nghiên cứu về y học
• tài liệu về y học
• cách trình bày báo cáo
• Neonatal septicemia
• Sepsis screen
• Early diagnosis of neonatal septicemia
• Communityacquired sepsis
• Bloodstream infections
• ESBL producers
• Molecular characterization
• Neonatal infection
• Antibiotic resistance
• Neonatal septicaemia
• A bacteriological study
• C reactive protein
• Hematological parameters
• Hematological markers in neonatal sepsis
• Early diagnosis