TAILIEUCHUNG - A study of Metallo-beta-lactamase producing pseudomonas Aeruginosa isolates in a Tertiary care Hospital

Metallo-beta-lactmase producing Pseudomonas aeruginosa strains are responsible for several nosocomial outbreaks in tertiary care centres across the world. It is well known that poor outcome occurs when patients with serious infections due to MBL producing organisms are treated with antibiotics to which the organism is completely resistant. Therefore, detection of MBL producing Pseudomonas aeruginosa strains is crucial for optimal treatment of critically ill patients and to prevent the spread of resistance. Aim of the present study is to detect Metallo-beta-lactmase (MBL) production in clinical isolates of Pseudomonas aeruginosa by Imipenem-EDTA Double Disc Synergy test. 100 strains of Pseudomonas aeruginosa isolated from pus, sputum, urinary catheter tip, blood and body fluids were screened for Carbapenem resistance by Kirby-Bauer disk diffusion method and results were interpreted as per CLSI guidelines. The isolates showing resistant to Imipenem were further tested for MBL production by Imipenem-EDTA Double Disc Synergy test. Out of 100 Pseudomonas aeruginosa strains 15 were resistant to Imipenem. Out of 15 isolates 10 were MBL producers. Proper antibiotic policy and measures to restrict the indiscriminative use of cephalosporins and carbapenems should be taken to minimize the emergence of Metallo-beta-lactmase producing pathogens. | A study of Metallo-beta-lactamase producing pseudomonas Aeruginosa isolates in a Tertiary care Hospital

• Y khoa - Dược
• Metallo beta lactamase
• Producing pseudomonas Aeruginosa isolates
• Aeruginosa isolates
• Pseudomonas aeruginosa
• Multidrug resistance
• Hospital acquired infections
• Extended spectrum beta lactamases
• Beta lactamase prevalence
• Multidrug resistance burden
• Incidence rate
• Antimicrobial resistance
• Central venous catheter blood stream infections
• Multidrug resistance pattern in confirmed cases
• Multidrug resistance pattern
• Penicillin resistance
• Streptococcus pneumoniae
• Tertiary care hospital
• Study of penicillin resistance
• Pre extensively drug resistance
• Extensively drug resistance
• Pulmonary multidrug resistant tuberculosis
• Patient by line probe assay
• Reliable methods
• Microbial Drug Resistance
• Ecology of Antibiotic Resistance Genes
• Multidrug Efflux Pumps
• Bacterial Resistance to Antimicrobials
• Global Response Systems That Confer Resistance
• Mechanisms of Aminoglycoside Antibiotic Resistance
• Efflux activity
• Efflux pumps
• Antibiotic withdrawal
• Multidrug resistant Escherichia coli
• Multidrug resistance associated protein 1
• Natural products
• P glycoprotein
• BMC Cancer
• UDP glucose ceramide glycosyltransferase
• Sphingolipid metabolism
• GSL metabolic pathway
• Luận án Tiến sĩ
• Summary of Biology doctoral thesis
• Biology doctoral thesis
• Multidrug resistant Salmonella
• Related genes
• Resistance characteristics
• Methicillin resistant staphylococcus aureus
• Tertiary care rural hospital
• Investigate their sensitivity pattern
• Summary of Doctoral Thesis in Biology
• Doctoral Thesis in Biology
• Preventive bundle
• Catheter associated urinary tract infection
• BMC Pharmacology and Toxicology
• p toluenesulfonyl hydrazinothiazoles
• Bacterial multidrug resistance
• Wnt/β catenin signaling
• Molecular docking
• Burn patients
• Resistance pattern
• Changing trends in resistance pattern
• Multidrug resistant E coli isolated
• Showing high resistance
• Multi drug resistance
• Antibacterial agents
• Vitro sensitivity towards
• ZnO phytonanocomposite
• Strychnos nux vomica
• Antibacterial activity
• Strychnos nux vomica L
• Drinking water
• Antibiotic resistance
• Multidrug resistant salmonella spp
• Potable water collected
• Slum areas of Bhopal
• Optical density
• Cartwheel method
• Efflux pump activity
• Multidrug resistant
• E coli isolates
• Extracellular vesicles
• Immune evasion
• Cell engulfment
• Door handles
• Microbial contamination
• Multidrug resistant staphylococcus aureus
• Door handles as potential reservoirs
• BMC Pulmonary Medicine
• Mechanical ventilator weaning
• Bacterial pneumonia
• Antimicrobial therapy
• Crosssectional study
• Various clinical samples
• Tertiary care centre Jhalawar
• Biofilm producing uropathogens
• Drug resistance
• Dual foe for patients
• Patients on urinary catheter
• Outer membrane proteins
• Multidrugresistant Klebsiella isolates
• Minimal inhibitory concentrations
• Mechanism of resistance
• Resistance patterns of the tested isolates