TAILIEUCHUNG - Specific antiproliferative activity against several human cancer cells with metabolites from Onygena corvina

We succeeded in large volume artificial cultivation of Onygena corvina. The appearance (shape, color, and size) of fruiting bodies of cultured bacteria was almost the same as that of wild one. We screened their metabolites for antiproliferative activities against nine human cancer cells in vitro. Culture filtrates (metabolite-containing media) of O. corvina were lyophilized and resuspended in phosphate buffer to investigate them in vitro. As a result, these metabolites effectively inhibited the growth of some cancer cells in a concentration-dependent manner. In particular, the effect on lung carcinoma Hara cells was remarkable, but there was almost no effect on hepatoma HepG2 cells. In addition, almost no effect was exerted on three normal cells [human hepatocyte (NHH), human mammary epithelial cells (NHME), and human epidermal melanocytes (NHEM)] at the same concentration. Therefore, it was revealed that the human cell proliferation inhibitory effect of the O. corvina metabolites greatly differs in susceptibility depending on the type of cancer cell under the concentration range not affecting normal cells. | Specific antiproliferative activity against several human cancer cells with metabolites from Onygena corvina

• Y khoa - Dược
• Onygena corvina
• Antitumor activity
• Cell specificity
• Medicinal plants
• Lung carcinoma
• BMC Cancer
• Squamous cell carcinoma
• Acantholytic squamous cell carcinoma
• Lymphogenous metastasis
• Small cell lung carcinoma
• Parathyroid hormone
• Lung squamous carcinoma
• Lung adenocarcinoma
• Peripheral monocyte count
• Lung cancer
• Adenosquamos carcinoma
• Genetic profiling
• Driver mutation
• PIK3CA mutation
• BMC Pulmonary medicine
• Anti TIF1γ self antibody
• Case report
• Malignant tumors
• Non small cell lung carcinoma
• mRNA expression
• Primary lung cancer
• Diagnostic role of Ciz1b
• Lung cancer patients
• Lung sarcomatoid carcinoma
• Non small cell lung cancer
• Receiver operating characteristic
• Tissue microarray
• Anaplastic lymphoma kinase
• Lung squamous cell carcinoma
• Lung adenocarcinoma patients
• Immunohistochemical findings
• Chronic obstructive pulmonary disease
• Tumor infiltrating immune cells
• Transbronchial needle aspiration
• Severe airway stenosis
• Prognostic model
• Bioinformatic analysis
• Solitary ocular metastasis
• Multidisciplinary treatment
• Small cell lung cancer
• Distal metastases
• Therapeutic potential
• Human lung cancer
• SK MES 1 lung carcinoma cell growth
• Insulin receptor isoform A
• Squamous cell carcinomas
• Adenocarcinoma in situ
• Distinct gene mutations
• Epidermal growth factor receptor
• Non small cell lung cancers
• Histological features
• Lung cancers
• Brain derived neurotrophic factor
• Promote tumorigenesis
• Human malignancies
• Claudin 3
• Cytoskeletal structural protein
• Various human cancers
• Quantitative real time polymerase chain reaction
• BMC Pharmacology and Toxicology
• Pulmonary sarcomatoid carcinoma
• Progression free survival
• Immune checkpoint inhibitors
• Adenosquamous carcinoma
• Competing risk analysis
• Cumulative incidence
• Renal cell carcinoma
• Lung metastases
• Radiofrequency ablation
• Local treatment
• Lung adenosquamous carcinoma
• Surgery resection
• Pathological subtypes
• SCC predominant ASC
• Leucine zipper EF hand containing transmembrane protein 1
• Cancer stemness
• Overall survival
• Papillary thyroid carcinoma
• Autism spectrum disorder
• Distant metastases
• Spread through air spaces
• Fanconi anemia
• ATM kinase inhibition radiosensitizes cells
• Selectively kills cells