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We succeeded in large volume artificial cultivation of Onygena corvina. The appearance (shape, color, and size) of fruiting bodies of cultured bacteria was almost the same as that of wild one. We screened their metabolites for antiproliferative activities against nine human cancer cells in vitro. Culture filtrates (metabolite-containing media) of O. corvina were lyophilized and resuspended in phosphate buffer to investigate them in vitro. As a result, these metabolites effectively inhibited the growth of some cancer cells in a concentration-dependent manner. In particular, the effect on lung carcinoma Hara cells was remarkable, but there was almost no effect on hepatoma HepG2 cells. In addition, almost no effect was exerted on three normal cells [human hepatocyte (NHH), human mammary epithelial cells (NHME), and human epidermal melanocytes (NHEM)] at the same concentration. Therefore, it was revealed that the human cell proliferation inhibitory effect of the O. corvina metabolites greatly differs in susceptibility depending on the type of cancer cell under the concentration range not affecting normal cells. | Specific antiproliferative activity against several human cancer cells with metabolites from Onygena corvina
