TAILIEUCHUNG - Protein kinase expression as a predictive factor for interferon response in chronic hepatitis C patients

Egypt has the highest prevalence of hepatitis C virus (HCV) worldwide. Currently, combined pegylated interferon and ribavirin therapy are the standard treatment. The biological activity of interferon (IFN) is mediated by the induction of intracellular antiviral proteins, such as 20 –50 oligoadenylate synthetase, and dsRNA-activated protein kinase. IFN-inducible doublestranded RNA-activated protein kinase (PKR) is thought to play a key antiviral role against HCV. Some studies observed that PKR expression was higher in sustained viral responders compared with the non-responders. The PKR is considered as antiviral toward HCV and responsible for IFN’s effect against HCV while others have showed that, there were kinetic results indicate that HCV infection is not altered by reduced levels of PKR, indicating that HCV is resistant to the translational inhibitory effects of the phosphorylated forms of PKR. This study was conducted on 50 consecutive patients with chronic HCV infection (CHC) and 20 healthy controls. All the patients were subjected to clinical and laboratory assessment, abdominal ultrasound, and liver biopsy. Determination of PKR gene quantity by using a real time PCR was done at the baseline and at the end of treatment for all patients and controls. Pre-treatment levels of protein kinase gene were significantly higher in responders in comparison with non-responders (P | Protein kinase expression as a predictive factor for interferon response in chronic hepatitis C patients

• Y khoa - Dược
• Chronic hepatitis C
• Pegylated Interferon
• Protein kinase gene
• Sustained virologic response
• Protein kinase expression
• Hepatocellular carcinoma
• Hepatitis C virus
• Direct acting antiviral agents
• Treating chronic hepatitis C infection
• Sequence heterogeneity in the core
• NS5A region of hepatitis C Virus
• IL 28B polymorphisms in predicting treatment response
• Chronic HCV genotype 4 infected
• BMC Cancer
• Hepatitis B virus
• Cancer risk
• Chronic hepatitis infection
• Confidence intervals
• Interferon lambda 3
• Hepatic steatosis
• Chronic hepatitis cirrhosis
• Chronic liver disease
• Hepatitis C virus infection
• Chronic liver disease patients
• Tertiary care hospital
• Primary hepatocellular carcinoma
• BMC Musculoskeletal Disorders
• Human immunodeficiency virus
• Chronic HCV monoinfection
• Ascertain joint pain
• Hepatitis C virus genotype 4
• Chronic hepatitis
• Promoter methylation
• Disease progression
• H pylori
• Liver fibrosis
• Helicobacter DNA
• Helicobacter pylori infection
• Soluble programmed cell death ligand 1
• Programmed cell death 1
• Sustained virological response
• Ornithine carbamoyltransferase
• Liver cirrhosis
• Bio plex suspension array
• Incidence of HCC
• Body mass index
• New era for management
• Chronic hepatitis C virus
• Antiviral agents
• Direct antiviral agents
• Protease inhibitors
• Polymerase inhibitors
• Flow cytometric detection
• Natural killer cells
• Natural killer T cells changes
• Blood of patients
• Chronic hepatitis C virus infection
• Egyptian university hospital
• Promising epigenetic approaches targeting TH17
• Chronic hepatitis C infection
• Key proinflammatory cytokine secreted
• Histone modification
• TH17 and autoimmune diabetes
• Chronic kidney disease
• Blood transfusion
• Maintenance hemodialysis
• Occult HCV
• Peripheral blood mononuclear cells
• Direct acting antiviral drugs
• Sofosbuvir and daclatasvir
• Ovarian cancer
• Surgery on hepatic patient
• BMC Bioinformatics
• Informational spectrum method
• Hepatitis C
• Muscarinic receptor type 3
• Cross reactivity
• Autonomic nervous system
• BMC Genomics
• Intra host hepatitis C virus
• Ultra Deep Sequencing
• Chronic HCV infection
• Molecular mechanisms
• Radiofrequency ablation
• Microwave ablation
• Clinical outcomes
• Lymphocyte monocyte ratio
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• báo cáo y học
• công trình nghiên cứu về y học
• tài liệu về y học
• cách trình bày báo cáo
• Acute kidney injury
• Kidney disease
• HCV is highly endemic imposes
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• tài liệu báo cáo khoa học
• nghiên cứu y học
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