TAILIEUCHUNG - Selective determination of dimenhydrinate in presence of six of its related substances and potential impurities using a direct GC/MS method

A novel simple, direct and selective gas chromatography–mass spectrometry (GC/MS) procedure was developed for the determination of the antihistamine drug dimenhydrinate (DMH) in presence of six of its related substances and potential impurities, namely, diphenylmethane, diphenylmethanol, benzophenone, orphenadrine, caffeine and 8-chlorocaffeine. The method involved resolution of the underivatized compounds using a trifluoropropylmethyl polysiloxane (Rtx-200) capillary column and the mass spectrometric detection was carried out in the electronimpact (EI) mode. Excellent baseline separation of DMH and the cited related substances was achieved in less than 15 min. Quantification of the parent drug DMH was based on measuring its peak area. The reliability and analytical performance of the proposed method were validated with respect to linearity, range, precision, accuracy, specificity, robustness, detection and quantification limits. Calibration curve of DMH was linear over the range 50–500 lg/mL with determination coefficient (R2 ) = . The proposed method was successfully applied for the assay of DMH in tablets dosage form with recoveries >. | Selective determination of dimenhydrinate in presence of six of its related substances and potential impurities using a direct GC/MS method

• Hoá học
• Related substances
• Tablet dosage form
• Selective determination
• Dimenhydrinate in presence
• Potential impurities
• BMC Chemistry
• Spiked human plasma
• THF protein precipitation
• Anti diabetic drug
• BMC Musculoskeletal Disorders
• Mental stress
• Algesic substances
• Multivariate correlation
• Oxygenation indicators
• báo cáo khoa học
• báo cáo y học
• công trình nghiên cứu về y học
• tài liệu về y học
• cách trình bày báo cáo
• BMC Pharmacology and Toxicology
• Opioid related disorders
• Increasing considerably
• Psychotropic substances
• DSM IV diagnostic criteria
• Journal of Botany
• Antioxidant system
• Extreme halophyte
• Inorganic ion
• Salt tolerance
• Signal compound