TAILIEUCHUNG - Evaluation of 90-day repeated dose oral toxiciy an androgenic activity of the Truong Xuan CB capsules in rats

To evaluate 90-day repeated dose oral toxicity and androgenic activity of the Truong Xuan CB capsule in rats. Subject and method: 90-day repeated dose oral toxicity were evaluated on rats follow the OECD 408 Guideline; androgenic activity were evaluated on castrateperipubertal male rats follow the OECD 441 Guideline. Results: The Truong Xuan CB capsule at doses g/kg/day and g/kg/day for 90 days continuously has no effect on the general condition of the rats, the body weight increase, hematological and biochemical indicators; histopathology of spleen, kidney and liver were normal. The Truong Xuan CB capsule at doses g/kg/day and g/kg/day showed an androgenic properties when evaluated in the Hershberger assay, increases the weight of the secondary sexual organs including the seminal vesicles, the ventral prostate, Cowper’s gland, glans penis and the levator ani-bulbocavernosus muscle in the experimental rats. Conclusion: Truong Xuan CB capsules were safe and had androgenic activity when evaluated in experimental rats. | Evaluation of 90-day repeated dose oral toxiciy an androgenic activity of the Truong Xuan CB capsules in rats

• Y khoa - Dược
• Evaluation of 90 day repeated dose oral toxiciy
• Repeated dose oral toxiciy
• Androgenic activity
• Truong Xuan CB capsules in rats
• Androgenic activity