TAILIEUCHUNG - Biochemistry essential: Part 2

(BQ) Contniued part 1, part 2 of the document Biochemistry essential has contents: Oxidative phosphorylation and mitochondrial diseases, glycogen metabolism and glycogen storage diseases, gluconeogenesis and fasting hypoglycemia, insulin and counterregulatory hormones,. and other contents. Invite you to refer. | Chapter 23 Oxidative Phosphorylation and Mitochondrial Diseases SYNOPSIS Mitochondria are basically stripped-down gram-negative bacteria that specialize in energy production. Human mitochondria consist of an internal compartment the mitochondrial matrix that contains the enzymes of the citric acid cycle fatty acid p-oxidation ketone body metabolism and parts of several biosynthetic pathways. The matrix is enclosed by the inner mitochondrial membrane which contains the proteins for oxidative phosphorylation. The inner mitochondrial membrane is surrounded by an outer mitochondrial membrane that is permeable to small molecules. The region between the two membranes is the intermembrane space. Oxidative phosphorylation takes place in the mitochondria and couples the oxidation of reduced nicotinamide adenine dinucleotide NADH and other reduced compounds to the production of adenosine triphosphate ATP Fig. . As NADH is oxidized protons H are pumped out of the matrix into the intermembrane space as part of a series of oxidation-reduction reactions. An ATP synthase allows protons to flow back into the mitochondrial matrix and it uses the energy that is freed in this process to phosphorylate adenine diphosphate ADP to ATP. Mitochondria contain their own DNA. Mitochondria are inherited from only the mother. Some of the proteins needed for oxidative phosphorylation are encoded by the DNA in the mitochondria but most are derived from the DNA in the nucleus. Mitochondrial diseases give rise to deficient oxidative phosphorylation and consequently affect primarily cells and tissues that require a high rate of ATP production such as the central nervous system the heart and skeletal muscle. Pancreatic p -cells are also often affected since ATP synthesis is required for glucose sensing and insulin secretion. LEARNING OBJECTIVES For mastery off this topic you should be able to do the -following Describe the function cellular location and tissue distribution of the electron .

• Y khoa - Dược
• Netter’s essential biochemistry
• Counterregulatory hormones
• Fasting hypoglycemia
• Glycogen storage diseases
• Glycogen metabolism
• Oxidative phosphorylation
• BMC Cancer
• Anchorage independent
• Epidermal growth factor receptor gene
• Particularly glioblastomas
• Electron transport chain
• Cancer metabolism
• Proximity ligation assay
• Principles of biochemistry
• Lecture Principles of biochemistry
• Nguyên lý hóa sinh
• Biochemical compounds
• Energetics
• Anaerobic
• Anaplerotic reactions
• Oxidative phoshorylation
• Mitochondrial anatomy
• transport chain
• trình bày báo cáo
• tài liệu báo cáo khoa học
• báo cáo y học
• kiến thức y học
• nghiên cứu y học
• báo cáo hóa học
• công trình nghiên cứu về hóa học
• tài liệu về hóa học
• cách trình bày báo cáo
• medical report
• Scientific reports
• scientific research
• breast cancer
• biological activities
• gastric cancer
• các công trình y học
• báo cáo trên tạp chí Medical Sciences
• High Yield biochemistry
• Acid–Base relationships
• Amino acids
• Citric acid cycle
• Carbohydrate metabolism
• Lipid metabolism
• Lippincotts illustrated Q&A review of biochemistry
• TCA cycle and oxidative phosphorylation
• Fatty acid metabolism
• Amino acid metabolism
• Phospholipid metabolism
• Mitochondrial DNA
• Mitochondrial DNA disorders
• Mitochondrial DNA mutations
• Calcium homeostasis
• Nucleotide metabolism
• Nucleic acid structure
• Protein synthesis
• Electron transport
• Glucose catabolism
• Mitochondrial NADH dehydrogenase subunit 3
• Reactive oxygen species
• Cell death
• Apoptosis inducing factor
• Enzymatic activity
• Kidney renal clear cell carcinoma
• Neoadjuvant treatment
• BMC Genomics
• Alzheimer’s disease
• Increasing disease incidence
• Early onset familial Alzheimer’s disease
• Pathogenic mechanisms
• Animal models
• Athletic performance
• Sprint athletes
• Chagas disease
• Reduviid bugs
• Trypanosoma cruzi
• Acetyl CoA
• N acetyltransferase
• Aerobic glycolysis
• Pyruvate dehydrogenase
• Pyruvate dehydrogenase kinase
• Lecture Biochemistry
• Biological phenomena
• Living systems
• Structure of cells
• BMC Pediatrics
• Linear skin defects
• HSSC gene
• Mitochondrial respiratory chain
• Acute myeloid leukemia
• Fusion gene
• Dysregulated proliferation
• Chromosomal translocation
• Cashmere goat
• During postnatal life
• Metabolic pathways
• Native chickens
• RNA seq
• Residual feed intake
• Feed efficiency