TAILIEUCHUNG - Early gastric cancer: From basic knowledge to understanding how to find it by endoscopy: Review

Early gastric cancer is defined as invasive gastric cancer that invades no more deeply than the submucosa, irrespective of lymph node metastasis (T1, any N). The need for better approaches to the treatment of early gastric cancer has led to the development of advanced endoscopic techniques to diagnosis and resect early gastric cancer. | Journal of military pharmaco-medicine no8-2018 EARLY GASTRIC CANCER: FROM BASIC KNOWLEDGE TO UNDERSTANDING HOW TO FIND IT BY ENDOSCOPY: REVIEW Dao Truong Giang1; Duong Xuan Nhuong1 SUMMARY Early gastric cancer is defined as invasive gastric cancer that invades no more deeply than the submucosa, irrespective of lymph node metastasis (T1, any N). The need for better approaches to the treatment of early gastric cancer has led to the development of advanced endoscopic techniques to diagnosis and resect early gastric cancer. This review aims: To guide gastrointestinal doctor to understand early gastric cancer from basic histologic knowledge and the usefulness of conventional endoscopy to advanced endoscopy to diagnose early gastric cancer. * Keywords: Gastric cancer; Endoscopy. DEFINITION The concept of early gastric cancer (EGC) was originated in Japan in 1962. At that time, an EGC was defined as a neoplasm that could be successfully treated with surgery. EGC is now defined more specifically as an adenocarcinoma that is restricted to mucosa or submucosa, irrespective of lymph node metastasis (T1, any N). These cancers have a significantly better prognosis (approximately 90% five-year survival rate) than do more advanced stages of gastric cancer. In Japan, gastric cancer screening began in the 1960s, and was continued to be the leading cause of cancer mortality. There has been a transition to magnification chromo-endoscopy with indigo-carmine spray in experienced centers in Eastern Asia. In addition, there is variation in screening practices by country and region. Methods used to screen for gastric cancer include endoscopy, H. pylori serology, and serum pepsinogen testing. HISTOLOGICAL CLASSIFICATION Gastric cancers can be classified in a number of ways, according to both histological and macroscopic findings. 1. Lauren classification. Histologically, gastric cancers are classified as intestinal (well-, moderately-, poorlydifferentiated) or diffuse .

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• Gastric cancer
• Lymph node metastasis
• Endoscopic techniques
• Early gastric cancer
• Magnifying endoscopy
• BMC Cancer
• Gastric cancer incidence
• Population based specialized registry
• Gastric cancer survival
• Gastric cancer clinical characteristics
• Gastric cancer pathological characteristics
• Gastroesophageal junction cancer
• Gastric cancer genomics
• Gastric cancer sequencing
• Gastric neoplasm
• D2 lymphadenectomy
• Advanced gastric cancer
• Gastric cancer surgery
• Cancer associated fibroblast
• Anti apoptosis
• Tumor cells
• Non cancerous gastric fibroblasts
• Transcription factors
• Cancer cell growth
• Potential therapeutic
• Emerging evidence
• Cancer development
• Transwell migration
• Matrigel invasion
• Cancer screening
• Discrete choice experiment
• Overall survival
• Gastric lymphoma
• Metachronous gastric adenocarcinoma
• Diffuse large B cell lymphoma
• Primary gastric lymphoma
• Diffuse gastric cancer
• Magnetic resonance imaging
• Heterogeneous enhancement
• BALB/c nude mice model
• Human originated gastric cancer cell
• Immune infiltration
• RNA seq data
• Stomach adenocarcinoma
• Tumor infiltrating immune cells
• Programmed cell death 1
• Tumor immunity
• Immune cells besides T cells
• Palliative chemotherapy
• Combination chemotherapy
• Germline mutation
• Central America
• CA 4
• Case report
• Splenic metastasis
• Epstein Barr virus
• Stomach cancer
• Gastric carcinoma
• Meta analysis
• Cetuximab combined
• Metastatic gastric cancer
• Identify potential biomarkers
• Target drugs
• Recurrent gastric cancer
• Traditional chemotherapy
• Mouse models
• Human gastric cancer
• Tumor formation
• Plasma membrane
• Tumor biomarkers
• Plasma membrane proteins participate
• Vascular endothelial growth factor
• 5 fluorouracil
• Single nucleotide polymorphisms
• HER2 positive recurrent
• Primary metastatic gastric cancer
• Trastuzumab based chemotherapy
• Severe postoperative complications
• Receiver operating characteristic
• Surgical gastric cancer
• Propensity score
• Adjuvant treatment
• Localized gastric cancer
• DNA sequencing
• CDH1 mutations
• Cell adhesion protein
• Mixed gastric cancer
• Metastasis associated lung adenocarcinoma transcript 1
• Cancer globally
• Non coding RNAs
• Including gastric cancer