TAILIEUCHUNG - Evaluation of acute toxicity of pidotimod synthesized in Vietnam

Objectives: In this study, the acute toxicity of pidotimod synthesized in Vietnam have been evaluated. Materials are synthetic pidotimod offered by Hanoi University of Pharmacy. Equipments and chemicals used for the study was calibrated according to ISO/IEC 17025. | Journal of military pharmaco-medicine n09-2018 EVALUATION OF ACUTE TOXICITY OF PIDOTIMOD SYNTHESIZED IN VIETNAM Quach Thi Ha Van1; Nguyen Hong Hai1; Nguyen Thi Thu Hang2 Nguyen Hai Nam2; Tran Viet Hung3 SUMMARY Objectives: In this study, the acute toxicity of pidotimod synthesized in Vietnam have been evaluated. Materials are synthetic pidotimod offered by Hanoi University of Pharmacy. Equipments and chemicals used for the study was calibrated according to ISO/IEC 17025. Method: Acute toxicity was evaluated according to the acute toxicity determination method (Medical Publishing House 1996) and the OECD guidelines (OECD guidelines for testing of chemicals. Acute oral toxicity - fixed dose procedure OECD 420, 2001). Results: Acute toxicity of pidotimod by oral administration in mice, LD50 was ± g/kg. Conclusion: The synthesized pidotimod sample (P120513) belongs to the class of non-toxic substances. * Keywords: Pidotimod; Acute toxicity. INTRODUCTION Pidotimod is an immunostimulant that has been synthesized since the late 1980s. Pidotimod increases 100% of T lymphocytes and 133% of NK cell activity in immune deficiency individuals. On some volunteers, pidotimod also increases the number of white blood cells and macrophages [5]. In addition to effects on the immune system, studies have shown that pidotimod has no effect on other organ systems in laboratory animals, safe for infants even after long periods of treatment [5]. Pidotimod has been used extensively in foreign countries, but in Vietnam market, axil (400 mg/7 mL) is the only circulation of pidotimod, but is imported at high prices. Step by step self-sufficiency of pharmaceutical raw materials for domestic drug production is one of the key tasks of the pharmaceutical industry in Vietnam. Hanoi University of Pharmacy has built the process of synthesizing and purifying. Pidotimod reached purity of . In order to make the appropriate dosage forms, therapeutic and safety results, we have .

• Y khoa - Dược
• Acute toxicity
• Pidotimod synthesized in Vietnam
• Hanoi University of Pharmacy
• Non toxic substances
• Synthesized pidotimod
• Phytosome silybin
• Sub acute toxicity
• Experimental animal
• Human prostate cancer cells
• BMC Pharmacology and Toxicology
• Acute oral toxicity
• Subchronic oral toxicity
• Human small cell carcinoma of lung
• Therapeutic applications
• In vivo toxicity limits
• Bacillus subtilis
• Bacillus coagulans
• Semi chronic toxicity
• Litchfield Wilcoxon method
• Ecological toxicology
• Zebrafish (Danio rerio)
• Zebrafish at different pH levels
• Acute toxicity of nickel
• Histological changes
• Nile tilapia (Oreochromis niloticus)
• Glyphosate herbicide
• Acute toxicity of glyphosate herbicide
• Organophosphate insecticide dichlorvos
• Fingerlings of Cyprinus carpio
• Cyprinus carpio
• Acute toxicity test
• Sub acute dermal toxicity
• Morinda citrifolia
• Pathomorphology in dermal toxicity
• Gold Nano particles
• Wistar rats
• Medical research
• Tri 02 powder
• Sub chronic toxicity
• Experimental animals
• Recreational drugs
• Psychoactive substances
• Novel psychoactive substances
• Psychiatric disorders
• BMC Cancer
• Acute skin toxicity
• Breast cancer
• Genetic polymorphisms
• Large breast size
• Quality of life
• Journal of Zoology
• Acute cadmium toxicity
• Histopathological findings
• Lithium borate
• Sperm morphology
• Moderate oedematous
• Definitive chemoradiation
• Esophageal cancer
• Irresectable esophageal cancer
• Natural sciences and technology
• Acute toxicity of cigarette
• In vivo model zebrafish larvae
• Toxicological test
• Zebrafish larvae
• Carbohydrate polymers
• Bacterial cellulose
• C3A hepatoma cells
• Lactate dehydrogenase
• In vivo genotoxic potential
• Herbal formulation
• Livestock feed
• Phyto chemical characterization
• Copper toxicity testing
• Gammarus pulex
• Water copper concentrations
• Copper accumulation rate
• Gammarus pulex L
• Tạp chí khoa học
• Tạp chí y dược
• Y dược quân sự
• Subchronic toxicity
• Testin CT3
• Peripheral toxicity
• Oxidative stress
• MDMA’s neurotoxicity
• Brain areas
• Weight loss
• Cervical cancer
• Hematological toxicity
• Toxicity during chemoradiotherapy
• Early stage disease
• Acute radiation toxicity
• Endothelial cells
• Angiopoietin 1
• Diffuse reflectance spectroscopy
• Wound healing
• Radiation therapy
• Acute skin damage
• Hypofractionated radiotherapy
• Postoperative treatment
• Acute lymphoblastic leukemia
• Reduced intensity multi centric clinical study
• Chemotherapy toxicity
• Event free survival
• Acute toxicity of zinc
• Survival time
• Lethality time
• Idotea baltica
• Least toxic
• Rectal cancer
• 3D conformal radiotherapy
• Volumetric modulated arc therapy
• Tumor regression grading