TAILIEUCHUNG - Cytotoxic steroids from the mushroom Ganoderma australe collected in Laos
Their structures were characterized by the combination of HR-MS, one and two dimensional NMR spectroscopic analyses. In addition, ergosterol peroxide and kansenone showed good cytotoxicity against four cancer cell lines, KB (human epidermal carcinoma), MCF7 (human breast carcinoma), SK-LU-1 (human lung carcinoma) and Hep-G2 (hepatocellular carcinoma). This is the first report on the chemical constituents and cytotoxic steroids from Ganoderma sp. in Laos. | Vietnam Journal of Chemistry, International Edition, 54(6): 688-691, 2016 DOI: Cytotoxic steroids from the mushroom Ganoderma australe collected in Laos Onesy Keomanykham1,2, Vong Anatha Khamko3, Bounpong Keorodom3, Sitha Khemmarath3, Dang Ngoc Quang1* 1 Faculty of Chemistry, Hanoi National University of Education, Hanoi 2 Luang Namtha Teacher Training College, Luang Namtha, Laos 3 Savannakhet University, Kayson Phomvihan, Savannakhet, Laos Received 11 July 2016; Accepted for publication 19 December 2016 Abstract Five steroids named stigmasterol (1), ergosterol peroxide (2), ganodertriol M (3), lucidumol B (4) and kansenone (5) were purified from the ethyl acetate extract of fruit bodies of the mushroom Ganoderma australe collected in Savannakhet province, Laos. Their structures were characterized by the combination of HR-MS, one and two dimensional NMR spectroscopic analyses. In addition, ergosterol peroxide and kansenone showed good cytotoxicity against four cancer cell lines, KB (human epidermal carcinoma), MCF7 (human breast carcinoma), SK-LU-1 (human lung carcinoma) and Hep-G2 (hepatocellular carcinoma). This is the first report on the chemical constituents and cytotoxic steroids from Ganoderma sp. in Laos. Keywords. Ganoderma australe, steroid, cytotoxic. 1. INTRODUCTION Ganoderma australe (Ganodermataceae family) is a common perennial bracket fungus that causes white heart rot in trees of the genera Tilia (limes), Quercus (oaks), Fagus (beech, birch etc), Platanus (Sycamore etc). It distributes most common in central and northern Europe. It also can be found in Nghean, Thuathienhue provinces, Vietnam and Dongphouvieng National forest, Sanvannaket province, Laos [1]. Phytochemical investigation on the fruit bodies of this mushroom revealed lanostane triterpenoids with antimicrobial activity [2-5]. In addition, Ganoderma australe collected in Nghean province, Vietnam was reported to have ergosta-4,22-diene-3-one and .
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