TAILIEUCHUNG - Cytotoxicity and antiviral activity of palladium(II) and platinum(II) complexes with 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone

Metal coordination compounds have an important role in the development of novel drugs. Using the resazurin microtitration assay we assessed the cytotoxicity and antiviral activity of the ligand 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone and its Pd(II) and Pt(II) complexes. | Turkish Journal of Biology Turk J Biol (2016) 40: 661-669 © TÜBİTAK doi: Research Article Cytotoxicity and antiviral activity of palladium(II) and platinum(II) complexes with 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone 1, 2 3 3 2 Vera SIMIĆ *, Stoimir KOLAREVIĆ , Ilija BRČESKI , Dejan JEREMIĆ , Branka VUKOVIĆ-GAČIĆ 1 National Control Laboratory, Medicines and Medical Devices Agency of Serbia, Belgrade, Serbia 2 Chair of Microbiology, Center for Genotoxicology and Ecogenotoxicology, Faculty of Biology, University of Belgrade, Belgrade, Serbia 3 Faculty of Chemistry, University of Belgrade, Belgrade, Serbia Received: Accepted/Published Online: Final Version: Abstract: Metal coordination compounds have an important role in the development of novel drugs. Using the resazurin microtitration assay we assessed the cytotoxicity and antiviral activity of the ligand 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone and its Pd(II) and Pt(II) complexes. Cytotoxicity was tested in A549 human lung adenocarcinoma epithelial cells. We observed that the ligand displayed a more pronounced cytotoxic activity than the platinum-based drug, carboplatin. Morphological evaluation of A549 cells treated with the ligand by acridine orange and ethidium bromide double staining revealed the presence of signs of apoptosis. Antiviral activity against poliovirus type 1 was assessed by examination of the cytopathic effect (CPE) in Hep-2 cells. Cells that were exposed to the 19 µM ligand before infection displayed a maximal significant reduction (by ± ) of the CPE. This was likely due to the inhibition of virus receptors and prevention of viral adsorption. Treatment with 17 µM Pt(II) complex after viral infection caused a maximal significant reduction (by ± ) of the CPE, presumably through an effect on viral replication. The results indicate that the ligand

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