TAILIEUCHUNG - Ebook Organic synthesis strategy and control: Part 2

(BQ) Part 2 book "Organic synthesis strategy and control" has contents: Resolution, kinetic resolution, strategy of asymmetric synthesis, functionalisation of pyridine; oxidation of aromatic compounds, enols and enolates, oxidation of aromatic compounds, enols and enolates, asymmetric induction IV substrate based strategy,.and other contents. | 22 Resolution Resolution Introduction and an example (1-phenylethylamine) Choice and Preparation of a Resolving Agent Resolving a hydroxy-acid on a large scale Resolving a hydroxy-amine on a large scale Resolving an amino-acid on a large scale Resolution via covalent compounds Advantages and Disadvantages of the Resolution Strategy When to Resolve General rule: resolve as early as possible Resolution of Diastereoisomers Resolution of compounds made as diastereoisomeric mixtures The synthesis of Jacobsen’s Mn(III) epoxidation catalyst by resolution Resolution with half an equivalent of resolving agent Physical Separation of Enantiomers Chromatography on chiral columns Resolution of triazole fungicides by HPLC A commercial drug separation by chiral HPLC Differential Crystallisation or Entrainment of Racemates Conglomerates and racemic compounds Typical procedure for differential crystallisation (entrainment) Conventional resolution of L-methyl DOPA Resolution of L-methyl DOPA by differential crystallisation Finding a differential crystallisation approach to fenfluramine Resolution with Racemisation Resolution of amino acids by differential crystallisation with racemisation Differential crystallisation and racemisation when enolisation is impossible Kinetic resolution with racemisation Other methods of racemisation during resolution: the Mannich reaction Resolution with racemisation in the manufacture of a drug Resolution with Enzymes Enzymes as resolving agents Resolution by ester hydrolysis with enzymes Resolutions of secondary alcohols by lipases Kinetic resolution with proteolytic enzymes Kinetic resolution with racemisation using proteolytic enzymes Organic Synthesis: Strategy and Control, Written by Paul Wyatt and Stuart Warren Copyright © 2007 John Wiley & Sons, Ltd 436 22 Resolution Kinetic resolution on diastereoisomeric mixtures Comparison between enzymatic and classical resolution Asymmetric Synthesis of a Prostaglandin with many Chiral .

• Hoá học
• Organic synthesis strategy
• Kinetic resolution
• Asymmetric synthesis
• Functionalisation of pyridine
• Oxidation of aromatic compounds
• Aromatic compounds
• Asymmetric induction
• Alternative strategies
• Enone synthesis
• Extended enolates
• The michael reaction
• Specific enol equivalents
• Electrophilic attack
• Organic synthesis
• The disconnection approach introduces
• Basic principles
• Amine synthesis
• General strategy
• Pyrrole Strategy
• Organocatalysis
• Alkene Metathesis
• Macrolactonization
• Enantioselective Reduction
• Carryback Financing
• Partnerships
• Pancreatic Lesion
• Coagulation Disorders
• Clinical Implications
• Expandable Metallic
• Sea urchin
• Left right asymmetry
• Symmetry breakage
• Left right organizer
• Asymmetric nodal induction