TAILIEUCHUNG - Cardioprotective effect of diazepam on ischemia-reperfused isolated hyperthyroid rat heart

Hyperthyroidism increases the vulnerability of the heart to ischemia-reperfusion (I/R) injury. Regarding the fact that diazepam also affects cardiac I/R injury, the current study was conducted to investigate the effect of diazepam on ischemia-reperfused isolated hyperthyroid rat heart. | Turk J Biol 36 (2012) 598-605 © TÜBİTAK doi: Cardioprotective effect of diazepam on ischemia-reperfused isolated hyperthyroid rat heart Dareuosh SHACKEBAEI1, Atefeh ASADMOBINI2, Mahvash HESARI1, Maryam VAEZI2, Siamak SHAHIDI3 1 Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah - IRAN 2 Department of Biology, Hamadan Branch, Islamic Azad University, Hamadan - IRAN 3 Department of Physiology, Hamadan University of Medical Sciences, Hamadan - IRAN Received: ● Accepted: Abstract: Hyperthyroidism increases the vulnerability of the heart to ischemia-reperfusion (I/R) injury. Regarding the fact that diazepam also affects cardiac I/R injury, the current study was conducted to investigate the effect of diazepam on ischemia-reperfused isolated hyperthyroid rat heart. The animals were divided into 6 groups: the control, hyperthyroid, control diazepam (1 mg/kg), hyperthyroid diazepam (1 mg/kg), control diazepam (5 mg/kg), and hyperthyroid diazepam (5 mg/kg) groups. Langendorff-perfused rat hearts underwent 40 min of global ischemia and 45 min of reperfusion. Different cardiac parameters, including the left ventricular developed pressure, heart rate, coronary flow, and rate pressure product (RPP), were measured. Lactate dehydrogenase (LDH) release was determined in reperfusion to evaluate the severity of the myocardial injury. The results showed that the RPP recovery percentage significantly decreased in the hyperthyroid group compared with control group, whereas comparison of the hyperthyroid diazepam (1 mg/kg) with the control and control diazepam (1 mg/kg) groups did not reveal a significant difference. These results were confirmed by LDH test, demonstrating that administration of diazepam (1 mg/kg) protected the heart against I/R injury in the hyperthyroid group and significantly decreased the I/R injury, which was probably due to the function of diazepam as a phosphodiesterase 4 .

• Sinh học
• Isolated heart
• Ischemia reperfusion
• Hyperthyroid rat heart
• Lactate dehydrogenase
• Cyclic adenosine monophosphate
• The study on clinical phenotypes
• Pulmonary hypertension
• Left heart disease
• Pre operation time in patients
• Isolated mitral valve replacement
• Double valve replacement
• BMC Pediatrics
• Alpha 2 adrenoceptors
• Mitigate bupivacaine induced cardiotoxicity
• Cardiotoxicity induced
• scientific reports
• Report medicine
• traditional medicine
• Mitochondrial calcium overload has been implicated in the irreversible damage of reperfused heart
• Accordingly
• we studied the effect of an oxy gen bridged dinuclear ruthenium amine complex (Ru360 )
• which is a select ive and potent mitochondrial calcium uniporter blocker
• on mitochondrial dysfunction and on the matrix free calcium concentration in mitochondria isolated from reperfused rat hearts
• báo cáo khoa học
• báo cáo y học
• công trình nghiên cứu về y học
• tài liệu về y học
• cách trình bày báo cáo
• tài liệu báo cáo nghiên cứu khoa học
• kiến thức bệnh thú y
• báo cáo bệnh thú y
• các nghiên về bệnh thú ý
• Lactococcus lactis subsp
• Lactococcin BZ
• Antimicrobial compound
• 16S rDNA gene sequence homology
• Brain heart infusion
• Ventricular septal defects
• Spontaneous closure
• Fetal echocardiography
• Congenital heart disease
• BMC Anesthesiology
• Anti arrhythmic
• Severe cardiotoxicity
• Ventricular arrhythmias
• Bupivacaine mixture
• Cardiac arrest
• Lipid emulsion
• Local anesthetic