TAILIEUCHUNG - Uterine fibroids

Uterine fibroids are the most common benign pelvic tumors in women of reproductive age. They affect 20–40% of those women1 but are found in 75% of hysterectomy specimens2. This is due to the mones fact that most fibroids are asymptomatic. Estimate of prevalence would need to be based on oultrasound screening. | 19 Uterine Fibroids Regine Unkels INTRODUCTION Uterine fibroids are the most common benign pelvic tumors in women of reproductive age. They affect 20-40 of those women1 but are found in 75 of hysterectomy specimens2. This is due to the fact that most fibroids are asymptomatic. A true estimate of prevalence would need to be based on ultrasound screening3. From ultrasound-based screening studies in the USA and Europe it is estimated that women have a risk of 50-70 of suffering from fibroids during their lifetime. Onset under the age of 30 years is rare although not impossible3. After menopause 12 months after the last period fibroids tend to decrease in size or remain stable. There are known risk factors for developing uterine fibroids but the true etiology is unknown. A genetic pre-condition for developing fibroids seems to exist that differs by ethnicity. From studies in the USA it is known that women of African descent more often have fibroids with an earlier onset bigger tumors and earlier symptoms than caucasian or Asian women3. Studies imply that this fact is due to different numbers of estrogen progesterone and aromatase receptors in fibroids and normal uterine muscle according to ethnicity. Fibroids can cause high morbidity and suffering when they grow and cause symptoms. Fibroid-associated morbidity in the USA results in direct costs of approximately 2 billion US dollar a year and fibroids are the most common indication for hysterectomy a major operation4. As a matter of fact every doctor will encounter patients with fibroid-associated symptoms once in a while depending on his or her workplace and it is worthwhile to sit down and think of how big the problem could be in your area. DEFINITION Uterine fibroids or leiomyoma are benign tumors of the uterine muscle called myometrium. They contain receptors for female reproductive hormones estrogen and progesterone and other enzyme receptors related to estrogen production aromatase receptors . When the receptors .

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