TAILIEUCHUNG - Colour Atlas Of Pharmacology 2nd Edition 2

(BQ) Part 2 book "Colour atlas of pharmacology" presentation of content: Hypnotics, psychopharmacologicals, local anesthetics, antibacterial drugs, antiviral drugs, therapy of selected diseases,. and other contents. | Antipyretic Analgesics High dose t1/2 =13-30h Low dose 201 50% Salicylic acid t1/2 =1-2h t1/2~3h 90% Acetylsalicylic acid 95% t1/2 =15min 99% 99% Diclofenac Ibuprofen Azapropazone t1/2 ~2h t1/2 =9-12h Piroxicam t1/2~50h 99% Naproxen 99% t1/2~14h Plasma protein binding A. Nonsteroidal antiinflammatory drugs (NSAIDs) Arachidonic acid Leukotrienes NSAID-induced nephrotoxicity Renal blood flow NSAID-induced gastropathy Prostaglandins Airway resistance Mucus production Acid secretion Mucosal blood flow NSAID-induced asthma B. NSAIDs: group-specific adverse effects Lüllmann, Color Atlas of Pharmacology © 2000 Thieme All rights reserved. Usage subject to terms and conditions of license. 202 Antipyretic Analgesics Thermoregulation and Antipyretics Body core temperature in the human is about 37 °C and fluctuates within ± 1 °C during the 24 h cycle. In the resting state, the metabolic activity of vital organs contributes 60% (liver 25%, brain 20%, heart 8%, kidneys 7%) to total heat production. The absolute contribution to heat production from these organs changes little during physical activity, whereas muscle work, which contributes approx. 25% at rest, can generate up to 90% of heat production during strenuous exercise. The set point of the body temperature is programmed in the hypothalamic thermoregulatory center. The actual value is adjusted to the set point by means of various thermoregulatory mechanisms. Blood vessels supplying the skin penetrate the heat-insulating layer of subcutaneous adipose tissue and therefore permit controlled heat exchange with the environment as a function of vascular caliber and rate of blood flow. Cutaneous blood flow can range from ~ 0 to 30% of cardiac output, depending on requirements. Heat conduction via the blood from interior sites of production to the body surface provides a controllable mechanism for heat loss. Heat dissipation can also be achieved by increased production of sweat, because evaporation of

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• Colour atlas of pharmacology
• Local anesthetics
• Antibacterial drugs
• Antiviral drugs
• Therapy of selected diseases
• General pharmacology
• Systems pharmacology
• cellular sites of action
• Distribution in the body
• Color Atlas of Pharmacology
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