TAILIEUCHUNG - Maternal and Child Health Handbook in Japan

Strategic Approach: 1) Utilize high throughput genomic/genetic platforms to characterize genetic susceptibility biomarkers of childhood cancer/cancer stem cells and to identify targets for novel tumour stem cell-directed molecular therapeutics, 2) develop advanced mechanisms and ethical/regulatory guidelines to conduct population-based genetic/genomic studies in children, 3) link biobanks to high-throughput functional analysis of individual tumours to assess responses to drugs and growth factors, adverse reactions to treatment, long-term side effects of treatment, and genome-wide expression of coding and non-coding RNA. Global Context: While 78% of childhood cancers are curable, this number drops to . | International Medical Community Maternal and Child Health Handbook in Japan JMAJ 53 4 259-265 2010 Yasuhide NAKAMURA 1 Key words Mothers Child Health Handbook Japan Drastic Upgrading of Maternal and Child Health in Japan Japan was itself a developing country just after the Second World War. After the Second World War the crude birth rate dropped sharply from per 1 000 people in 1947 to in 2007 Fig. 1 . The total fertility rate also declined rapidly from in 1947 to in There was a sharp fall of the birth rate about 26 fall of the previous year in 1966 a year without disaster or famine. This year was a Hinoeuma the year of the horse in the Chinese calendar when many couples did not want babies because of the traditional belief that girls born in a Hinoeuma year will be dangerous headstrong and generally bad luck for any husband. Most parents knew that there was no scientific evidence to confirm the effects of Hinoeuma. However many parents did not have babies this year because of this belief. Maternal and child health is one of the most conservative fields because each ethnic group has preserved its traditions related to pregnancy delivery and child-rearing. The infant mortality rate IMR has shown a drastic and constant decrease from in 1947 to in 2007 Fig. 2 . The IMR decreased by about 50 for every decade IMR was in 1950 in 1960 in 1970 in 1980 and in The decrease rate of IMR was constant and lower than the rate of decrease of the target of the Millennium Development Goals MDGs . The life expectancy at birth as of 2007 was years for females and for males. The female life expectancy is the longest in the world. A joint US and Japanese research team compared the IMR in Japan and the United States Fig. 3 . In 1950 the IMR in Japan was about double that of the US. However in 1964 the IMR in Japan dropped below that of the US despite the fact that Japan was still a poor country with GNP per capita

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