TAILIEUCHUNG - Báo cáo sinh học: "Probability-based model of protein-protein interactions on biological timescales"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí y học Molecular Biology cung cấp cho các bạn kiến thức về ngành sinh học đề tài: Probability-based model of protein-protein interactions on biological timescales. | Algorithms for Molecular Biology BioMed Central Research Probability-based model of protein-protein interactions on biological timescales Alexander L Tournier Paul W Fitzjohn and Paul A Bates Open Access Address Biomolecular Modelling Laboratory Cancer Research UK London Research Institute 44 Lincoln s Inn Fields London WC2A 3PX UK Email Alexander LTournier - Paul W Fitzjohn - Paul A Bates - Corresponding authors Published II December 2006 Received 25 September 2006 Algorithms for Molecular Biology 2006 1 25 doi 1748-7188-1 -25 Accepted 1 1 December 2006 This article is available from http content 1 1 25 2006 Tournier et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Simulation methods can assist in describing and understanding complex networks of interacting proteins providing fresh insights into the function and regulation of biological systems. Recent studies have investigated such processes by explicitly modelling the diffusion and interactions of individual molecules. In these approaches two entities are considered to have interacted if they come within a set cutoff distance of each other. Results In this study a new model of bimolecular interactions is presented that uses a simple probability-based description of the reaction process. This description is well-suited to simulations on timescales relevant to biological systems from seconds to hours and provides an alternative to the previous description given by Smoluchowski. In the present approach TFB the diffusion process is explicitly taken into account

• Báo cáo khoa học
• Báo cáo sinh học hay
• cách trình bày báo cáo
• báo cáo sinh học
• công trình nghiên cứu sinh học
• tài liệu về sinh học