TAILIEUCHUNG - Báo cáo khoa hoc : Multidrug resistance proteins (MRPs⁄ABCCs) in cancer chemotherapy and genetic diseases

The ATP-binding cassette (ABC) transporters are a superfamily of mem-brane proteins that are best known for their ability to transport a wide variety of exogenous and endogenous substances across membranes against a concentration gradient via ATP hydrolysis. | IFEBS Journal MINIREVIEW Multidrug resistance proteins MRPs ABCCs in cancer chemotherapy and genetic diseases Zhe-Sheng Chen and Amit K. Tiwari Department of PharmaceuticalSciences College of Pharmacy and Allied Health Professions St. John s University Queens NY USA Keywords ABCC transporters cancer chemotherapy cyclic nucleotides Dubin-Johnson syndrome genetic diseases GS-X efflux pump leukotriene C4 multidrug resistance multiple resistance protein Pseudoxanthoma elasticum Correspondence . Chen Department of Pharmaceutical Sciences College of Pharmacy and Allied Health Professions St. John s University Queens NY 11439 USA Fax 1 718 990 1877 Tel 1 718 990 1432 E-mail chenz@ Received 23 December 2010 revised 11 June 2011 accepted 5 July 2011 doi The ATP-binding cassette ABC transporters are a superfamily of membrane proteins that are best known for their ability to transport a wide variety of exogenous and endogenous substances across membranes against a concentration gradient via ATP hydrolysis. There are seven subfamilies of human ABC transporters one of the largest being the C subfamily gene symbol ABCC . Nine ABCC subfamily members the so-called multidrug resistance proteins MRPs 1-9 have been implicated in mediating multidrug resistance in tumor cells to varying degrees as the efflux extrude chemotherapeutic compounds or their metabolites from malignant cells. Some of the MRPs are also known to either influence drug disposition in normal tissues or modulate the elimination of drugs or their metabolites via hepatobiliary or renal excretory pathways. In addition the cellular efflux of physiologically important organic anions such as leukotriene C4 and cAMP is mediated by one or more of the MRPs. Finally mutations in several MRPs are associated with human genetic disorders. In this minireview the current biochemical and physiological knowledge of MRP1-MRP9 in cancer chemotherapy and human genetic disease is .

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