TAILIEUCHUNG - báo cáo khoa học: " Successful treatment of desmoid tumor of the chest wall with tranilast: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Successful treatment of desmoid tumor of the chest wall with tranilast: a case report | Goto et al. Journal of Medical Case Reports 2010 4 384 http content 4 1 384 jAg JOURNALOF medical ÌỤr case REPORTS CASE REPORT Open Access Successful treatment of desmoid tumor of the chest wall with tranilast a case report 1 2 1 1 2 Takahiro Goto Tetsuo Nemoto Koichi Ogura Takahiro Hozumi Nobuaki Funata Abstract Introduction Desmoid tumor is characterized by infiltrative growth and local recurrence often occurs after surgery. To reduce the local recurrence rate adjuvant therapy such as radiotherapy and pharmacotherapy with cytotoxic agents anti-estrogen agents and non-steroidal anti-inflammatory drugs is often applied. In addition these non-surgical treatments are also performed in patients with unresectable desmoid tumors. We successfully treated a patient with a desmoid tumor with tranilast an anti-allergic agent. Case presentation A 48-year-old Japanese man with a slow-growing desmoid tumor on his chest wall was treated with an oral administration of tranilast 300 mg per day three times a day . Two years and two months after the commencement of his therapy the tumor became impalpable. At this time the oral administration of tranilast was discontinued. Two years after discontinuation of the treatment a physical examination showed no recurrence of the tumor and he continued in a state of remission. We were successfully able to reduce the size of the tumor and thereafter maintain the reduced size. Conclusion Tranilast was clinically effective in our case and is probably comparable to cytotoxic agents or antiestrogen agents. Because tranilast has substantially fewer adverse effects than cytotoxic agents it could be a very useful therapeutic agent for desmoid tumor. Introduction Desmoid tumor defined as clonal fibroblastic proliferation arises in the deep soft tissue and is characterized by infiltrative growth and a tendency towards local recurrence but without the ability to metastasize. The standard and definitive treatment for desmoid

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