TAILIEUCHUNG - Low Occurrence of Tuberculosis Drug Resistance among Pulmonary Tuberculosis Patients froman Urban Setting, with a Long-Running DOTS Programin Zambia

We set out to determine the levels of Mycobacterium tuberculosis resistance to first- and second-line TB drugs in an urban population in Zambia. Sputum samples were collected consecutively from all smear-positive, new and previously treated patients, from four diagnostic centres in Ndola between January and July 2006. Drug susceptibility testing was performed using the proportion method against four first- and two second-line TB drugs. Results. Among 156 new cases, any resistance was observed to be , monoresistance to isoniazid and rifampicin was and , respectively. Of 31 retreatment cases, any resistance was observed to be , monoresistance to isoniazid and rifampicin was for. | Hindawi Publishing Corporation Tuberculosis Research and Treatment Volume 2010 Article ID 938178 6 pages doi 2010 938178 Research Article Low Occurrence of Tuberculosis Drug Resistance among Pulmonary Tuberculosis Patients from an Urban Setting with a Long-Running DOTS Program in Zambia Chanda Mulenga 1 2 Allan Chonde 1 Innocent C. Bwalya 1 Nathan Kapata 3 Mathilda Kakungu-Simpungwe 4 Sven Docx 2 Krista Fissette 2 Isdore Chola Shamputa 1 2 5 Francoise Portaels 2 and Leen Rigouts2 6 1 Biomedical Sciences Department Tropical Diseases Research Centre . Box 71769 Ndola Zambia 2 Mycobacteriology Unit Institute of Tropical Medicine Naionalestraat 155 B-2000 Antwerpen Belgium 3 National Tuberculosis and Leprosy Program Ministry of Health . Box 30205 Lusaka Zambia 4Ndola District Health Management Team . Box 70672 Ndola Zambia 5 Tuberculosis Research Section National Institutes of Health LCID NIAID Bethesda MD 20892 USA 6 Department of Biomedical Sciences University of Antwerp Campus Drie Eiken Universiteitsplein 1 2000 Antwerpen Belgium Correspondence should be addressed to Chanda Mulenga chandamulenga@ Received 2 December 2009 Revised 27 April 2010 Accepted 18 May 2010 Academic Editor Nalin Rastogi Copyright 2010 Chanda Mulenga et al. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. We set out to determine the levels of Mycobacterium tuberculosis resistance to first- and second-line TB drugs in an urban population in Zambia. Sputum samples were collected consecutively from all smear-positive new and previously treated patients from four diagnostic centres in Ndola between January and July 2006. Drug susceptibility testing was performed using the proportion method against four first- and two second-line TB drugs. Results. Among 156 new cases any resistance was observed to be .

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