TAILIEUCHUNG - Báo cáo khoa học: Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio

Over the past few decades, numerous small molecules have been designed to specifically and selectively target the unusual secondary structure in DNA called the G-quadruplex. Because these ligands have been shown to selectively inhibit the growth of cancer cells, they have become a central focus for the development of novel anticancer agents. | Identification and characterization of the transcription factors involved in T-cell development t-bet stat6 and foxp3 within the zebrafish Danio rerio Suman Mitra Ayham Alnabulsi Chris J. Secombes and Steve Bird Scottish Fish Immunology Research Centre Schoolof BiologicalSciences University of Aberdeen UK Keywords adaptive immunity fish immunology T-cells transcription factors zebrafish Correspondence S. Bird Scottish Fish Immunology Research Centre School of Biological Sciences Zoology Building University of Aberdeen Aberdeen AB24 2TZ UK Fax 44 1224 272396 Tel 44 1224 272881 E-mail Received 25 August 2009 revised 16 October 2009 accepted 27 October 2009 doi The discovery of cytokines expressed by T-helper 1 Th1 Th2 Th17 and T-regulatory Treg cells has prompted speculation that these types of responses may exist in fish arising early in vertebrate evolution. In this investigation we cloned three zebrafish transcription factors T-box expressed in T cells t-bet signal transducer and activator of transcription 6 stat6 and fork-head box p3 foxp3 in which two transcripts are present that are important in the development of a number of these cell types. They were found within the zebrafish genome using a synteny approach in the case of t-bet and foxp3. Multiple alignments of zebrafish t-bet stat6 and foxp3 amino acids with known vertebrate homologues revealed regions of high conservation subsequently identified to be protein domains important in the functioning of these transcription factors. The gene organizations of zebrafish t-bet and foxp3 were identical to those of the human genes with the second foxp3 transcript lacking exons 5 6 7 and 8. Zebrafish stat6 21 exons and 20 introns was slightly different from the human gene which contained 22 exons and 21 introns. Immunostimulation of zebrafish head kidney and spleen cells with phytohaemagglutinin lipopolysaccharide or Poly I C showed a correlation between the .

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