TAILIEUCHUNG - Báo cáo khoa học: "Stereotactic radiosurgery for brain metastases: analysis of outcome and risk of brain radionecrosis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Stereotactic radiosurgery for brain metastases: analysis of outcome and risk of brain radionecrosis. | Minniti et al. Radiation Oncology 2011 6 48 http content 6 1 48 RADIATION ONCOLOGY RESEARCH Open Access Stereotactic radiosurgery for brain metastases analysis of outcome and risk of brain radionecrosis 1 2 1 f I T- -3 Giuseppe Minniti 1 Enrico Clarke Gaetano Lanzetta Mattia Falchetto Osti Guido Trasimeni Alessandro Bozzao3 Andrea Romano3 and Riccardo Maurizi Enrici1 Abstract Purpose to investigate the factors affecting survival and toxicity in patients treated with stereotactic radiosurgery SRS with special attention to volumes of brain receiving a specific dose V10 - V16 Gy as predictors for brain radionecrosis. Patients and Methods Two hundred six consecutive patients with 310 cerebral metastases less than cm were treated with SRS as primary treatment and followed prospectively at University of Rome La Sapienza Sant Andrea Hospital. Overall survival brain control and local control were estimated using the Kaplan-Meier method calculated from the time of SRS. Univariate and multivariate analysis using a Cox proportional hazards regression model were performed to determine the predictive value of prognostic factors for treatment outcome and SRS-related complications. Results Median overall survival and brain control were months and 10 months respectively. The 1-year and 2-year survival rates were 58 and 24 and respective brain control were 43 and 22 . Sixteen patients recurred locally after SRS with 1-year and 2-year local control rates of 92 and 84 respectively. On multivariate analysis stable extracranial disease and KPS 70 were associated with the most significant survival benefit. Neurological complications were recorded in 27 13 patients. Severe neurological complications RTOG Grade 3 and 4 occurred in of patients. Brain radionecrosis occurred in 24 of treated lesions being symptomatic in 10 and asymptomatic in 14 . On multivariate analysis V10 through V16 Gy were independent risk factors for radionecrosis with V10 Gy and .

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