TAILIEUCHUNG - Báo cáo khoa học: "Combination therapy with docetaxel and S-1 as a first-line treatment in patients with advanced or recurrent gastric cancer: a retrospective analysis"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Combination therapy with docetaxel and S-1 as a first-line treatment in patients with advanced or recurrent gastric cancer: a retrospective analysis | Tanabe et al. World Journal of Surgical Oncology 2010 8 40 http content 8 1 40 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access Combination therapy with docetaxel and S-1 as a first-line treatment in patients with advanced or recurrent gastric cancer a retrospective analysis Kazuaki Tanabe 1 Takahisa Suzuki1 Noriaki Tokumoto1 Hideki Yamamoto1 Kazuhiro Yoshida2 and Hideki Ohdan1 Abstract Background We performed a single-institution retrospective study to evaluate the efficacy and toxicities of combination therapy with docetaxel and S-1 in patients with advanced or recurrent gastric cancer. Methods Eighty-six patients with advanced or recurrent gastric cancer were enrolled. Patients received docetaxel 40 mg m2 on day 1 and oral S-1 80 mg m2 day on days 1 to 14 every 3 weeks. Results All 84 patients were assessable for response. The overall response rate was 44 84 and the disease control rate was 81 84 . Median time to progression TTP and overall survival OS were 95 CI months and months 95 CI months respectively. The major toxicities were neutropenia leukopenia alopecia and anorexia. Grade 3 or 4 hematologic toxicities included neutropenia in 31 patients leukopenia in 27 febrile neutropenia in four and anemia in one . Other grade 3 toxicities included anorexia in five patients and stomatitis diarrhea and nausea in one each . There was one treatment-related death . Conclusion The combination of docetaxel and S-1 had good clinical activity with acceptable toxicity in patients with advanced or recurrent gastric cancer. Introduction Worldwide gastric cancer ranks second among causes of all cancer-related deaths with about 700 000 confirmed mortalities annually 1 . In Japan gastric cancer is still the second most frequent cause of cancer-related death despite advances in diagnosis and treatment. For patients with unresectable or recurrent gastric cancer outcomes are extremely poor with a

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