TAILIEUCHUNG - báo cáo hóa học: " CRP gene variation affects early development of Alzheimer’s disease-related plaques"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: CRP gene variation affects early development of Alzheimer’s disease-related plaques | Kok et al. Journal of Neuroinflammation 2011 8 96 http content 8 1 96 JOURNAL OF NEUROINFLAMMATION RESEARCH Open Access CRP gene variation affects early development of Alzheimer s disease-related plaques 1 2 1 3 1 4 Eloise Helena Kok Mervi Alanne-Kinnunen Karita Isotalo Teemu Luoto Satu Haikonen Sirkka Goebeler Markus Perola5 Mikko A Hurme1 Hannu Haapasalo1 and Pekka J Karhunen1 Abstract Introduction We used the Tampere Autopsy Study TASTY series n 603 age 0-97 yrs representing an unselected population outside institutions to investigate the pathogenic involvement of inflammation in Alzheimer s disease-related lesions. Methods We studied senile plaque SP neurofibrillary tangles NFT and SP phenotype associations with 6 reported haplotype tagging single nucleotide polymorphisms SNPs in the CRP gene. CRP and Ab immunohistochemistry was assessed using brain tissue microarrays. Results In multivariate analyses age- and APOE-adjusted non-neuritic SP were associated with the high-CRP TA-genotype prevalence of rs3091244 and CA-genotype of rs3093075 compared to common genotypes. Conversely the low-CRP C allele of rs2794521 reduced the risk of harbouring early non-neuritic SP compared to the TT genotype. CRP haplotype TAGCC high associated with non-neuritic SP whereas haplotype CCGCC offered protection. TT genotypes high of rs3091244 and rs1130864 were associated with CRP staining. There were no associations between SNPs or haplotypes and NFT. CRP staining of the hippocampal CA1 2 region correlated with Ab staining. Conclusions CRP gene variation affects early SP development in prodromal Alzheimer s disease independent of APOE genotype. Background The only method for definitive diagnosis of Alzheimer s disease AD to date is postmortem examination of the brain. Current understanding indicates that the neuro-pathological hallmarks senile plaques SP and neurofibrillary tangles NFT develop within the brain interrupting neuronal signalling

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